Dynamic arrest and aging of biomolecular condensates are modulated by low-complexity domains, RNA and biochemical activity

Miriam Linsenmeier; Maria Hondele; Fulvio Grigolato; Eleonora Secchi; Karsten Weis; Paolo Arosio

doi:10.1038/s41467-022-30521-2

Nature Communications (May 2022)

Dynamic arrest and aging of biomolecular condensates are modulated by low-complexity domains, RNA and biochemical activity

Miriam Linsenmeier,
Maria Hondele,
Fulvio Grigolato,
Eleonora Secchi,
Karsten Weis,
Paolo Arosio

Affiliations

Miriam Linsenmeier: Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, Swiss Federal Institute of Technology
Maria Hondele: Department of Biology, Institute for Biochemistry, Swiss Federal Institute of Technology
Fulvio Grigolato: Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, Swiss Federal Institute of Technology
Eleonora Secchi: Department of Civil, Environmental and Geomatic Engineering, Swiss Federal Institute of Technology
Karsten Weis: Department of Biology, Institute for Biochemistry, Swiss Federal Institute of Technology
Paolo Arosio: Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, Swiss Federal Institute of Technology

DOI: https://doi.org/10.1038/s41467-022-30521-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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Here the authors analyze material properties and aging of active phase-separated condensates by Differential Dynamic Microscopy. Arrested states are promoted by structured RNA. Low-complexity domains and biochemical reaction keep the droplets fluid-like.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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