Molecular & Cellular Oncology (Sep 2020)
Ser784 phosphorylation: a clinically relevant enhancer of VCP function in the DNA damage response
Abstract
Valosin-containing protein (VCP) is essential for proteostasis during many cellular processes. However, it remains uncertain how its diverse functions are selectively regulated. We recently showed that DNA damage-induced Ser784 phosphorylation specifically increases VCP function for the DNA damage response and significantly influences the survival of chemotherapy-treated breast cancer patients.
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