Identification of novel microRNA signatures linked to acquired aplastic anemia

Kohei Hosokawa; Pawel Muranski; Xingmin Feng; Keyvan Keyvanfar; Danielle M. Townsley; Bogdan Dumitriu; Jichun Chen; Sachiko Kajigaya; James G. Taylor; Christopher S. Hourigan; A. John Barrett; Neal S. Young

doi:10.3324/haematol.2015.126128

Haematologica (Dec 2015)

Identification of novel microRNA signatures linked to acquired aplastic anemia

Kohei Hosokawa,
Pawel Muranski,
Xingmin Feng,
Keyvan Keyvanfar,
Danielle M. Townsley,
Bogdan Dumitriu,
Jichun Chen,
Sachiko Kajigaya,
James G. Taylor,
Christopher S. Hourigan,
A. John Barrett,
Neal S. Young

Affiliations

Kohei Hosokawa: Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA
Pawel Muranski: Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA
Xingmin Feng: Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA
Keyvan Keyvanfar: Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA
Danielle M. Townsley: Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA
Bogdan Dumitriu: Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA
Jichun Chen: Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA
Sachiko Kajigaya: Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA
James G. Taylor: Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA
Christopher S. Hourigan: Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA
A. John Barrett: Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA
Neal S. Young: Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA

DOI: https://doi.org/10.3324/haematol.2015.126128
Journal volume & issue: Vol. 100, no. 12

Abstract

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Emerging evidence indicates that microRNA control and modulate immunity. MicroRNA have not been investigated in acquired aplastic anemia, a T-cell-mediated immune disease. Analysis of 84 microRNA expression levels in CD4+ and CD8+ T cells of patients with aplastic anemia revealed concurrent down-regulation of miR-126-3p, miR-145-5p, miR-223-3p, and miR-199a-5p (>3-fold change, P2-fold change, P

Published in Haematologica

ISSN: 0390-6078 (Print); 1592-8721 (Online)
Publisher: Ferrata Storti Foundation
Country of publisher: Italy
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the blood and blood-forming organs
Website: http://www.haematologica.org

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