Nature Communications (Aug 2022)
Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals
- Usman A. Tahir,
- Daniel H. Katz,
- Julian Avila-Pachecho,
- Alexander G. Bick,
- Akhil Pampana,
- Jeremy M. Robbins,
- Zhi Yu,
- Zsu-Zsu Chen,
- Mark D. Benson,
- Daniel E. Cruz,
- Debby Ngo,
- Shuliang Deng,
- Xu Shi,
- Shuning Zheng,
- Aaron S. Eisman,
- Laurie Farrell,
- Michael E. Hall,
- Adolfo Correa,
- Russell P. Tracy,
- Peter Durda,
- Kent D. Taylor,
- Yongmei Liu,
- W. Craig Johnson,
- Xiuqing Guo,
- Jie Yao,
- Yii-Der Ida Chen,
- Ani W. Manichaikul,
- Frederick L. Ruberg,
- William S. Blaner,
- Deepti Jain,
- NHLBI Trans-Omics for Precision Medicine 1 Consortium,
- Claude Bouchard,
- Mark A. Sarzynski,
- Stephen S. Rich,
- Jerome I. Rotter,
- Thomas J. Wang,
- James G. Wilson,
- Clary B. Clish,
- Pradeep Natarajan,
- Robert E. Gerszten
Affiliations
- Usman A. Tahir
- Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
- Daniel H. Katz
- Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
- Julian Avila-Pachecho
- Broad Institute of Harvard and MIT
- Alexander G. Bick
- Broad Institute of Harvard and MIT
- Akhil Pampana
- Broad Institute of Harvard and MIT
- Jeremy M. Robbins
- Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
- Zhi Yu
- Broad Institute of Harvard and MIT
- Zsu-Zsu Chen
- Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
- Mark D. Benson
- Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
- Daniel E. Cruz
- Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
- Debby Ngo
- Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
- Shuliang Deng
- Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
- Xu Shi
- Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
- Shuning Zheng
- Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
- Aaron S. Eisman
- Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
- Laurie Farrell
- Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
- Michael E. Hall
- University of Mississippi Medical Center
- Adolfo Correa
- University of Mississippi Medical Center
- Russell P. Tracy
- Department of Pathology Laboratory Medicine, Larner College of Medicine, University of Vermont
- Peter Durda
- Department of Pathology Laboratory Medicine, Larner College of Medicine, University of Vermont
- Kent D. Taylor
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center
- Yongmei Liu
- Department of Medicine, Division of Cardiology, Duke Molecular Physiology Institute, Duke University Medical Center
- W. Craig Johnson
- Department of Biostatistics, University of Washington
- Xiuqing Guo
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center
- Jie Yao
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center
- Yii-Der Ida Chen
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center
- Ani W. Manichaikul
- Center for Public Health Genomics, University of Virginia
- Frederick L. Ruberg
- Section of Cardiovascular Medicine, Boston University School of Medicine and Boston Medical Center
- William S. Blaner
- Columbia University Medical Center
- Deepti Jain
- University of Washington
- NHLBI Trans-Omics for Precision Medicine 1 Consortium
- Claude Bouchard
- Human Genomic Laboratory, Pennington Biomedical Research Center
- Mark A. Sarzynski
- Department of Exercise Science, University of South Carolina
- Stephen S. Rich
- Center for Public Health Genomics, University of Virginia
- Jerome I. Rotter
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center
- Thomas J. Wang
- Department of Medicine, UT Southwestern Medical Center
- James G. Wilson
- Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
- Clary B. Clish
- Broad Institute of Harvard and MIT
- Pradeep Natarajan
- Broad Institute of Harvard and MIT
- Robert E. Gerszten
- Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-022-32275-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Most studies of the genetics of the metabolome have been done in individuals of European descent. Here, the authors integrate genomics and metabolomics in Black individuals, highlighting the value of whole genome sequencing in diverse populations and linking circulating metabolites to human disease.
