Increased Expression of the Calcium-Activated Chloride Channel in Hclca1 in Airways of Patients with Obstructive Chronic Bronchitis

Hans-Peter Hauber; Celine Bergeron; Anne Tsicopoulos; Benoit Wallaert; Ron Olivenstein; Kenneth J Holroyd; Roy C Levitt; Qutayba Hamid

doi:10.1155/2005/531432

Canadian Respiratory Journal (Jan 2005)

Increased Expression of the Calcium-Activated Chloride Channel in Hclca1 in Airways of Patients with Obstructive Chronic Bronchitis

Hans-Peter Hauber,
Celine Bergeron,
Anne Tsicopoulos,
Benoit Wallaert,
Ron Olivenstein,
Kenneth J Holroyd,
Roy C Levitt,
Qutayba Hamid

Affiliations

Hans-Peter Hauber: Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada
Celine Bergeron: Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada
Anne Tsicopoulos: Institut Pasteur, Lille, France
Benoit Wallaert: Institut Pasteur, Lille, France
Ron Olivenstein: Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada
Kenneth J Holroyd: Genaera Corporation, Plymouth Meeting, Pennsylvania, USA
Roy C Levitt: Genaera Corporation, Plymouth Meeting, Pennsylvania, USA
Qutayba Hamid: Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada

DOI: https://doi.org/10.1155/2005/531432
Journal volume & issue: Vol. 12, no. 3
pp. 143 – 146

Abstract

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BACKGROUND: Interleukin (IL)-9 and its effect on enhancing the human calcium-activated chloride channel 1 (hCLCA1) expression have been shown to induce mucin production. Increased expression of hCLCA1 may, in turn, contribute to mucus overproduction in chronic obstructive pulmonary disease (COPD) with a chronic bronchitis (CB) phenotype.

Published in Canadian Respiratory Journal

ISSN: 1198-2241 (Print); 1916-7245 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the respiratory system
Website: https://onlinelibrary.wiley.com/journal/7503

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