Risk Factors Related to Poor Outcomes in the Treatment of Non-conventional Periprosthetic Infection

Abstract

Abstract Objectives To identify the main risk factors related to poor outcomes after the treatment for periprosthetic infection. Materials and Methods Medical records from 109 patients who underwent non-conventional endoprosthesis surgeries (primary and revision procedures) from January 1’ 2007’ to December 31’ 2018’ were retrospectively evaluated. In total’ 15 patients diagnosed with periprosthetic infection were eligible to participate in the study. Variables including gender’ ageatdiagnosis’ affected bone’ surgery duration’white blood cell (WBC) count before endoprosthesis placement’ urinary tract infection during the first postoperative year, and time elapsed from endoprosthesis placement to infection diagnosis were related to outcomes using the Fisherexact test (for the bicategorical variables) or analysis of variance (ANOVA’ for the tricategorical variables). The mean times from diagnosis to final outcome were compared using the Student t-test. Results These risk factors did not show a statistically significant correlation with the outcomes. The data revealed a trend towards a difference between the mean time for the onset of infection and the final outcome. Due to the limited sample, we believe that studies with larger cohorts can prove this trend. Conclusion We identified that the time from endoprosthesis placement to the onset of the symptoms of infection tends to be related to the outcome and evolution of the patient evolution during the treatment for periprosthetic infection. Although apparently correlated, other associated factors were not statistically linked to poor treatment outcomes.

Keywords

• prosthesis and implants
• sarcoma
• infections
• osteosarcoma
• amputation
• debridement