Characteristics of Gut Microbiota in Patients With Clear Cell Renal Cell Carcinoma

Yang Chen; Junjie Ma; Yunze Dong; Ziyu Yang; Na Zhao; Qian Liu; Wei Zhai; Junhua Zheng

doi:10.3389/fmicb.2022.913718

Frontiers in Microbiology (Jul 2022)

Characteristics of Gut Microbiota in Patients With Clear Cell Renal Cell Carcinoma

Yang Chen,
Junjie Ma,
Yunze Dong,
Ziyu Yang,
Na Zhao,
Qian Liu,
Wei Zhai,
Junhua Zheng

Affiliations

Yang Chen: Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Junjie Ma: Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Yunze Dong: Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine in Tongji University, Shanghai, China
Ziyu Yang: Department of Laboratory Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Na Zhao: Department of Laboratory Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Qian Liu: Department of Laboratory Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Wei Zhai: Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Junhua Zheng: Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

DOI: https://doi.org/10.3389/fmicb.2022.913718
Journal volume & issue: Vol. 13

Abstract

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Different gut microbiota is implicated in different diseases, including cancer. However, gut microbiota differences between individuals with clear cell renal cell carcinoma (ccRCC) and healthy individuals are unclear. Here, we analyzed gut microbiota composition in 51 ccRCC patients and 40 healthy controls using 16S rRNA sequencing analysis. We observed that Blautia, Streptococcus, [Ruminococcus]_torques_group, Romboutsia, and [Eubacterium]_hallii_group were dominant and positively associated with ccRCC. We isolated and cultured Streptococcus lutetiensis to characterize specific gut microbiota that promotes ccRCC and found that it promoted in vitro ccRCC proliferation, migration, and invasion via the TGF-signaling pathway. Interactions identified between the gut microbiota and ccRCC suggest the gut microbiota could serve as a potential non-invasive tool for predicting ccRCC risk and also function as a cancer therapy target.

Published in Frontiers in Microbiology

ISSN: 1664-302X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/journals/microbiology

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