STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells

Lin Jin; Yunjia Chen; David K. Crossman; Arunima Datta; Trung Vu; James A. Mobley; Malay Kumar Basu; Mariangela Scarduzio; Hengbin Wang; Chenbei Chang; Pran K. Datta

doi:10.1038/s41467-020-19698-6

Nature Communications (Nov 2020)

STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells

Lin Jin,
Yunjia Chen,
David K. Crossman,
Arunima Datta,
Trung Vu,
James A. Mobley,
Malay Kumar Basu,
Mariangela Scarduzio,
Hengbin Wang,
Chenbei Chang,
Pran K. Datta

Affiliations

Lin Jin: Division of Hematology and Oncology, Department of Medicine, UAB Comprehensive Cancer Center, University of Alabama at Birmingham
Yunjia Chen: Department of Genetics, University of Alabama at Birmingham
David K. Crossman: Department of Genetics, University of Alabama at Birmingham
Arunima Datta: Division of Hematology and Oncology, Department of Medicine, UAB Comprehensive Cancer Center, University of Alabama at Birmingham
Trung Vu: Division of Hematology and Oncology, Department of Medicine, UAB Comprehensive Cancer Center, University of Alabama at Birmingham
James A. Mobley: Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham
Malay Kumar Basu: Department of Pathology, University of Alabama at Birmingham
Mariangela Scarduzio: Department of Neurology, Center for Neurodegeneration and Experimental Therapeutic, University of Alabama at Birmingham
Hengbin Wang: Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham
Chenbei Chang: Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham
Pran K. Datta: Division of Hematology and Oncology, Department of Medicine, UAB Comprehensive Cancer Center, University of Alabama at Birmingham

DOI: https://doi.org/10.1038/s41467-020-19698-6
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 18

Abstract

Read online

STRAP (serine threonine kinase receptor-associated protein) promotes tumorigenicity. Here the authors report that STRAP associates with spliceosome and regulates alternative splicing during embryonic stem cell lineage commitment and early mouse embryo organogenesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal