IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function

Chiara Montemurro; Hiroshi Nomoto; Lina Pei; Vishal S. Parekh; Kenny E. Vongbunyong; Suryakiran Vadrevu; Tatyana Gurlo; Alexandra E. Butler; Rohan Subramaniam; Eleni Ritou; Orian S. Shirihai; Leslie S. Satin; Peter C. Butler; Slavica Tudzarova

doi:10.1038/s41467-019-10444-1

Nature Communications (Jun 2019)

IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function

Chiara Montemurro,
Hiroshi Nomoto,
Lina Pei,
Vishal S. Parekh,
Kenny E. Vongbunyong,
Suryakiran Vadrevu,
Tatyana Gurlo,
Alexandra E. Butler,
Rohan Subramaniam,
Eleni Ritou,
Orian S. Shirihai,
Leslie S. Satin,
Peter C. Butler,
Slavica Tudzarova

Affiliations

Chiara Montemurro: Larry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles
Hiroshi Nomoto: Larry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles
Lina Pei: Larry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles
Vishal S. Parekh: Department of Pharmacology and Brehm Diabetes Research Center, University of Michigan
Kenny E. Vongbunyong: Larry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles
Suryakiran Vadrevu: Department of Pharmacology and Brehm Diabetes Research Center, University of Michigan
Tatyana Gurlo: Larry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles
Alexandra E. Butler: Larry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles
Rohan Subramaniam: Larry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles
Eleni Ritou: Division of Endocrinology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles
Orian S. Shirihai: Division of Endocrinology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles
Leslie S. Satin: Department of Pharmacology and Brehm Diabetes Research Center, University of Michigan
Peter C. Butler: Larry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles
Slavica Tudzarova: Larry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles

DOI: https://doi.org/10.1038/s41467-019-10444-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 17

Abstract

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Type 2 diabetes is associated with islet amyloid deposits derived from islet amyloid polypeptide (IAPP) expressed by β-cells. Here the authors show that IAPP misfolded protein stress induces the hypoxia inducible factor 1 alpha injury repair pathway and activates survival metabolic changes mediated by PFKFB3.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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