Revista Cubana de Medicina (Jun 2004)
Lipoproteína (a) como factor de riesgo independiente de enfermedad cardiovascular aterosclerótica Lipoproten (a) as a risk factor independent of the atherosclerotic cardiovascular disease
Abstract
Con el objetivo de investigar la función que ejerce la lipoproteína (a) como factor de riesgo independiente en diferentes procesos cardiovasculares se determinaron los valores de la misma en 50 sujetos sin enfermedad arterial coronaria y en 92 pacientes isquémicos. Se determinaron las concentraciones de colesterol total, HDL, LDL, triglicéridos y VLDL. Aunque las concentraciones promedio de Lp(a) fueron superiores en los pacientes que en los controles, sólo se obtuvo diferencias significativas para el grupo angina (p=0,036*). Los factores de riesgo adicionales que mostraron valores patológicos fueron el colesterol total, las LDL, HDL y los triglicéridos con diferencias significativas para los 2 primeros de p In order to investigate the function of lipoprotein (a) as an independent risk factor in different cardiovascular processes, its values were determined in 50 subjects with no coronary arterial disease and in 92 ischemic patients. The concentrations of total cholesterol, HDL, LDL, triglycerides and VLDL were determined. Though the average concentrations of Lp(a) were higher in patients than in controls, significant differences were only obtained for the angina group (p=0.0368*). The aditional risk factors showing pathological values were total cholesterol, LDL, HDL and triglycerides with marked differences for the first two of p<0.05 and p<0.01. It was concluded that in our study lipoprotein(a) was a risk factor independent of cardiovascular disease. Therefore, its determination should be included in the clinical practices.
