Catalytical nano-immunocomplexes for remote-controlled sono-metabolic checkpoint trimodal cancer therapy

Chi Zhang; Jingsheng Huang; Ziling Zeng; Shasha He; Penghui Cheng; Jingchao Li; Kanyi Pu

doi:10.1038/s41467-022-31044-6

Nature Communications (Jun 2022)

Catalytical nano-immunocomplexes for remote-controlled sono-metabolic checkpoint trimodal cancer therapy

Chi Zhang,
Jingsheng Huang,
Ziling Zeng,
Shasha He,
Penghui Cheng,
Jingchao Li,
Kanyi Pu

Affiliations

Chi Zhang: School of Chemical and Biomedical Engineering, Nanyang Technological University
Jingsheng Huang: School of Chemical and Biomedical Engineering, Nanyang Technological University
Ziling Zeng: School of Chemical and Biomedical Engineering, Nanyang Technological University
Shasha He: School of Chemical and Biomedical Engineering, Nanyang Technological University
Penghui Cheng: School of Chemical and Biomedical Engineering, Nanyang Technological University
Jingchao Li: School of Chemical and Biomedical Engineering, Nanyang Technological University
Kanyi Pu: School of Chemical and Biomedical Engineering, Nanyang Technological University

DOI: https://doi.org/10.1038/s41467-022-31044-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Ultrasound-based therapies in combination with immune checkpoint blockade have been shown to improve the efficacy of cancer immunotherapy. Here the authors report the design of a pH-responsive and sono-irradiation activatable nanosystem functionalized with anti-PD-L1 and adenosine deaminase for sono-metabolic cancer immunotherapy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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