Mycemycins A–E, New Dibenzoxazepinones Isolated from Two Different Streptomycetes

Abstract

Five new dibenzoxazepinone derivatives, mycemycins A–E (1–5), were isolated from the ethanol extracts of mycelia of two different streptomycetes. 1 and 2 were isolated from an acidic red soil-derived strain, Streptomyces sp. FXJ1.235, and 3–5 from a gntR gene-disrupted deep-sea strain named Streptomyces olivaceus FXJ8.012Δ1741. The structures of mycemycins were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR techniques.

Keywords

• mycemycin
• dibenzoxazepinone
• deep-sea
• Streptomyces
• gene disruption