npj Microgravity (Feb 2024)
How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?
- Trent Davis,
- Kevin Tabury,
- Shouan Zhu,
- Debora Angeloni,
- Sarah Baatout,
- Alexandra Benchoua,
- Juergen Bereiter-Hahn,
- Daniele Bottai,
- Judith-Irina Buchheim,
- Marco Calvaruso,
- Eugénie Carnero-Diaz,
- Sara Castiglioni,
- Duccio Cavalieri,
- Gabriele Ceccarelli,
- Alexander Choukér,
- Francesca Cialdai,
- Gianni Ciofani,
- Giuseppe Coppola,
- Gabriella Cusella,
- Andrea Degl’Innocenti,
- Jean-Francois Desaphy,
- Jean-Pol Frippiat,
- Michael Gelinsky,
- Giada Genchi,
- Maria Grano,
- Daniela Grimm,
- Alain Guignandon,
- Christiane Hahn,
- Jason Hatton,
- Raúl Herranz,
- Christine E. Hellweg,
- Carlo Saverio Iorio,
- Thodoris Karapantsios,
- Jack J.W.A. van Loon,
- Matteo Lulli,
- Jeanette Maier,
- Jos Malda,
- Emina Mamaca,
- Lucia Morbidelli,
- Angelique van Ombergen,
- Andreas Osterman,
- Aleksandr Ovsianikov,
- Francesco Pampaloni,
- Elizabeth Pavezlorie,
- Veronica Pereda-Campos,
- Cyrille Przybyla,
- Christopher Puhl,
- Petra Rettberg,
- Angela Maria Rizzo,
- Kate Robson-Brown,
- Leonardo Rossi,
- Giorgio Russo,
- Alessandra Salvetti,
- Daniela Santucci,
- Matthias Sperl,
- Sara Tavella,
- Christiane Thielemann,
- Ronnie Willaert,
- Nathaniel Szewczyk,
- Monica Monici
Affiliations
- Trent Davis
- Heritage College of Osteopathic Medicine, Ohio University
- Kevin Tabury
- Laboratory of Radiobiology, Belgian Nuclear Research Centre, SCK CEN
- Shouan Zhu
- Heritage College of Osteopathic Medicine, Ohio University
- Debora Angeloni
- Institute of Biorobotics, Scuola Superiore Sant’Anna
- Sarah Baatout
- Laboratory of Radiobiology, Belgian Nuclear Research Centre, SCK CEN
- Alexandra Benchoua
- ISTEM, CECS, AFM-Téléthon
- Juergen Bereiter-Hahn
- Institute for Cell Biology and Neurobiology, Goethe University Frankfurt am Main
- Daniele Bottai
- Department Pharmaceutical Sciences, University of Milan
- Judith-Irina Buchheim
- Laboratory of “Translational Research, Stress & Immunity”, Department of Anesthesiology, LMU University Hospital Munich
- Marco Calvaruso
- Institute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR)
- Eugénie Carnero-Diaz
- Institute of Systematics, Evolution, Biodiversity, Sorbonne University, NMNH, CNRS, EPHE, UA
- Sara Castiglioni
- Department of Biomedical and Clinical Sciences, University of Milan
- Duccio Cavalieri
- Department of Biology, University of Florence
- Gabriele Ceccarelli
- Department of Public Health, Experimental Medicine and Forensic, University of Pavia
- Alexander Choukér
- Laboratory of “Translational Research, Stress & Immunity”, Department of Anesthesiology, LMU University Hospital Munich
- Francesca Cialdai
- ASAcampus Joint Laboratory, ASA Research Division, DSBSC-University of Florence
- Gianni Ciofani
- Smart Bio-Interfaces, Istituto Italiano di Tecnologia
- Giuseppe Coppola
- Institute of Applied Science and Intelligent Systems – CNR
- Gabriella Cusella
- Department of Public Health, Experimental Medicine and Forensic, University of Pavia
- Andrea Degl’Innocenti
- Department of Medical Biotechnologies, University of Siena, Italy and Smart Bio-Interfaces, IIT
- Jean-Francois Desaphy
- Department of Precision and Regenerative Medicine, University of Bari “Aldo Moro”
- Jean-Pol Frippiat
- Stress, Immunity, Pathogens Laboratory, SIMPA, Université de Lorraine
- Michael Gelinsky
- Centre for Translational Bone, Joint & Soft Tissue Research, TU Dresden
- Giada Genchi
- Smart Bio-Interfaces, Istituto Italiano di Tecnologia
- Maria Grano
- Department of Precision and Regenerative Medicine, University of Bari “Aldo Moro”
- Daniela Grimm
- Department of Microgravity and Translational Regenerative Medicine, Otto-von-Guericke-University Magdeburg, Germany & Dept of Biomedicine, Aarhus University
- Alain Guignandon
- SAINBIOSE, INSERM U1059, Université Jean Monnet
- Christiane Hahn
- European Space Agency, ESTEC
- Jason Hatton
- European Space Agency, ESTEC
- Raúl Herranz
- Centro de Investigaciones Biológicas Margarita Salas (CSIC)
- Christine E. Hellweg
- Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR)
- Carlo Saverio Iorio
- CREST-ATM, Université libre de Bruxelles
- Thodoris Karapantsios
- Faculty of Chemistry, Aristotle University of Thessaloniki
- Jack J.W.A. van Loon
- Amsterdam University Medical Center, ACTA/VU
- Matteo Lulli
- Department of Experimental and Clinical Biomedical Sciences, University of Florence
- Jeanette Maier
- Department of Biomedical and Clinical Sciences, University of Milan
- Jos Malda
- Department of Orthopaedics, University Medical Center Utrecht & Department of Clinical Sciences, Utrecht University
- Emina Mamaca
- European and International Affairs Department, Ifremer centre Bretagne
- Lucia Morbidelli
- Department of Life Sciences, University of Siena
- Angelique van Ombergen
- European Space Agency, ESTEC
- Andreas Osterman
- Max von Pettenkofer Institute, Virology, LMU Munich & DZIF, Partner Site Munich
- Aleksandr Ovsianikov
- 3D Printing and Biofabrication, Institute of Materials Science and Technology, TU Wien
- Francesco Pampaloni
- Buchmann Inst. for Molecular Life Sciences, Goethe-Universität Frankfurt am Main
- Elizabeth Pavezlorie
- Ludwig Boltzmann Institute for Traumatology, Research Center in Cooperation with AUVA
- Veronica Pereda-Campos
- GSBMS/URU EVOLSAN - Medecine Evolutive, Université Paul Sabatier Toulouse III
- Cyrille Przybyla
- MARBEC, Université de Montpellier, CNRS, Ifremer, IRD
- Christopher Puhl
- Space Applications NV/SA for European Space Agency
- Petra Rettberg
- DLR, Institute of Aerospace Medicine, Research Group Astrobiology
- Angela Maria Rizzo
- Department of Pharmacological and Biomolecular Sciences, University of Milan
- Kate Robson-Brown
- Department of Engineering Mathematics, and Department of Anthropology and Archaeology, University of Bristol
- Leonardo Rossi
- Department of Clinical and Experimental Medicine, University of Pisa
- Giorgio Russo
- Institute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR)
- Alessandra Salvetti
- Department of Clinical and Experimental Medicine, University of Pisa
- Daniela Santucci
- Center for Behavioural Sciences and Mental Health, Istituto Superiore Sanità
- Matthias Sperl
- DLR-MP
- Sara Tavella
- IRCCS Ospedale Policlinico San Martino and University of Genoa, DIMES
- Christiane Thielemann
- BioMEMS lab, University of Applied Sciences Aschaffenburg
- Ronnie Willaert
- Research Group NAMI and NANO, Vrije Universiteit Brussels
- Nathaniel Szewczyk
- Heritage College of Osteopathic Medicine, Ohio University
- Monica Monici
- ASAcampus Joint Laboratory, ASA Research Division, DSBSC-University of Florence
- DOI
- https://doi.org/10.1038/s41526-024-00357-9
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 7
Abstract
Abstract Progress in mechanobiology allowed us to better understand the important role of mechanical forces in the regulation of biological processes. Space research in the field of life sciences clearly showed that gravity plays a crucial role in biological processes. The space environment offers the unique opportunity to carry out experiments without gravity, helping us not only to understand the effects of gravitational alterations on biological systems but also the mechanisms underlying mechanoperception and cell/tissue response to mechanical and gravitational stresses. Despite the progress made so far, for future space exploration programs it is necessary to increase our knowledge on the mechanotransduction processes as well as on the molecular mechanisms underlying microgravity-induced cell and tissue alterations. This white paper reports the suggestions and recommendations of the SciSpacE Science Community for the elaboration of the section of the European Space Agency roadmap “Biology in Space and Analogue Environments” focusing on “How are cells and tissues influenced by gravity and what are the gravity perception mechanisms?” The knowledge gaps that prevent the Science Community from fully answering this question and the activities proposed to fill them are discussed.
