Acoustic metamaterials-driven transdermal drug delivery for rapid and on-demand management of acute disease

Junhua Xu; Hongwei Cai; Zhuhao Wu; Xiang Li; Chunhui Tian; Zheng Ao; Vivian C. Niu; Xiao Xiao; Lei Jiang; Marat Khodoun; Marc Rothenberg; Ken Mackie; Jun Chen; Luke P. Lee; Feng Guo

doi:10.1038/s41467-023-36581-2

Nature Communications (Feb 2023)

Acoustic metamaterials-driven transdermal drug delivery for rapid and on-demand management of acute disease

Junhua Xu,
Hongwei Cai,
Zhuhao Wu,
Xiang Li,
Chunhui Tian,
Zheng Ao,
Vivian C. Niu,
Xiao Xiao,
Lei Jiang,
Marat Khodoun,
Marc Rothenberg,
Ken Mackie,
Jun Chen,
Luke P. Lee,
Feng Guo

Affiliations

Junhua Xu: Department of Intelligent Systems Engineering, Indiana University
Hongwei Cai: Department of Intelligent Systems Engineering, Indiana University
Zhuhao Wu: Department of Intelligent Systems Engineering, Indiana University
Xiang Li: Department of Intelligent Systems Engineering, Indiana University
Chunhui Tian: Department of Intelligent Systems Engineering, Indiana University
Zheng Ao: Department of Intelligent Systems Engineering, Indiana University
Vivian C. Niu: Department of Intelligent Systems Engineering, Indiana University
Xiao Xiao: Department of Bioengineering, University of California, Los Angeles
Lei Jiang: Department of Intelligent Systems Engineering, Indiana University
Marat Khodoun: Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati
Marc Rothenberg: Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati
Ken Mackie: Gill Center for Biomolecular Science, and Department of Psychological and Brain Sciences, Indiana University
Jun Chen: Department of Bioengineering, University of California, Los Angeles
Luke P. Lee: Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Feng Guo: Department of Intelligent Systems Engineering, Indiana University

DOI: https://doi.org/10.1038/s41467-023-36581-2
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 9

Abstract

Read online

Treating acute disease like anaphylaxis is challenging due to the inability to administer therapeutics in a timely manner and regulate pharmacokinetics precisely within a short time window. Here the authors develop active acoustic metamaterials-driven transdermal drug delivery for rapid and on-demand acute disease management.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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