Nature Communications (Nov 2019)
EGFL9 promotes breast cancer metastasis by inducing cMET activation and metabolic reprogramming
- Fanyan Meng,
- Ling Wu,
- Lun Dong,
- Allison V. Mitchell,
- C. James Block,
- Jenney Liu,
- Haijun Zhang,
- Qing Lu,
- Won-min Song,
- Bin Zhang,
- Wei Chen,
- Jiani Hu,
- Jian Wang,
- Qifeng Yang,
- Maik Hüttemann,
- Guojun Wu
Affiliations
- Fanyan Meng
- Barbara Ann Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine
- Ling Wu
- Barbara Ann Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine
- Lun Dong
- Barbara Ann Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine
- Allison V. Mitchell
- Barbara Ann Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine
- C. James Block
- Barbara Ann Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine
- Jenney Liu
- Center for Molecular Medicine and Genetics, Wayne State University
- Haijun Zhang
- College of Life Sciences, Huaibei Normal University
- Qing Lu
- Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University
- Won-min Song
- Department of Genetics and Genomic Sciences, Icahn Institute of Genomics and Multiscale Biology, Icahn Mount Sinai School of Medicine
- Bin Zhang
- Department of Genetics and Genomic Sciences, Icahn Institute of Genomics and Multiscale Biology, Icahn Mount Sinai School of Medicine
- Wei Chen
- Barbara Ann Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine
- Jiani Hu
- Department of Radiology, Wayne State University MRI Core
- Jian Wang
- Department of Pathology, Wayne State University
- Qifeng Yang
- Department of Breast Surgery, Qilu Hospital, Shandong University
- Maik Hüttemann
- Center for Molecular Medicine and Genetics, Wayne State University
- Guojun Wu
- Barbara Ann Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-019-13034-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
Triple-negative breast cancer is an aggressive form of the disease. Here, the authors identify EGFL9 as a mediator of metastasis in TNBC through interactions with cMET.
