Nature Communications (Jan 2016)
Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes
- Minako Imamura,
- Atsushi Takahashi,
- Toshimasa Yamauchi,
- Kazuo Hara,
- Kazuki Yasuda,
- Niels Grarup,
- Wei Zhao,
- Xu Wang,
- Alicia Huerta-Chagoya,
- Cheng Hu,
- Sanghoon Moon,
- Jirong Long,
- Soo Heon Kwak,
- Asif Rasheed,
- Richa Saxena,
- Ronald C. W. Ma,
- Yukinori Okada,
- Minoru Iwata,
- Jun Hosoe,
- Nobuhiro Shojima,
- Minaka Iwasaki,
- Hayato Fujita,
- Ken Suzuki,
- John Danesh,
- Torben Jørgensen,
- Marit E. Jørgensen,
- Daniel R. Witte,
- Ivan Brandslund,
- Cramer Christensen,
- Torben Hansen,
- Josep M. Mercader,
- Jason Flannick,
- Hortensia Moreno-Macías,
- Noël P. Burtt,
- Rong Zhang,
- Young Jin Kim,
- Wei Zheng,
- Jai Rup Singh,
- Claudia H. T. Tam,
- Hiroshi Hirose,
- Hiroshi Maegawa,
- Chikako Ito,
- Kohei Kaku,
- Hirotaka Watada,
- Yasushi Tanaka,
- Kazuyuki Tobe,
- Ryuzo Kawamori,
- Michiaki Kubo,
- Yoon Shin Cho,
- Juliana C. N. Chan,
- Dharambir Sanghera,
- Philippe Frossard,
- Kyong Soo Park,
- Xiao-Ou Shu,
- Bong-Jo Kim,
- Jose C. Florez,
- Teresa Tusié-Luna,
- Weiping Jia,
- E Shyong Tai,
- Oluf Pedersen,
- Danish Saleheen,
- Shiro Maeda,
- Takashi Kadowaki
Affiliations
- Minako Imamura
- Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences
- Atsushi Takahashi
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Toshimasa Yamauchi
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo
- Kazuo Hara
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo
- Kazuki Yasuda
- Department of Metabolic Disorder, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine
- Niels Grarup
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Wei Zhao
- Department of Biostatistics and Epidemiology, University of Pennsylvania
- Xu Wang
- Saw Swee Hock School of Public Health, National University of Singapore
- Alicia Huerta-Chagoya
- Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas UNAM/Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
- Cheng Hu
- Department of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Sanghoon Moon
- Division of Structural and Functional Genomics, Center for Genome Science, National Institute of Health
- Jirong Long
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
- Soo Heon Kwak
- Department of Internal Medicine, Seoul National University Hospital
- Asif Rasheed
- Center for Non-Communicable Diseases
- Richa Saxena
- Center for Human Genetic Research, Massachusetts General Hospital
- Ronald C. W. Ma
- Department of Medicine and Therapeutics, The Chinese University of Hong Kong
- Yukinori Okada
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Minoru Iwata
- First Department of Internal Medicine, University of Toyama
- Jun Hosoe
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo
- Nobuhiro Shojima
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo
- Minaka Iwasaki
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo
- Hayato Fujita
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo
- Ken Suzuki
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo
- John Danesh
- Department of Public Health and Primary Care, University of Cambridge
- Torben Jørgensen
- Research Centre for Prevention and Health, Capital Region of Denmark
- Marit E. Jørgensen
- Steno Diabetes Center
- Daniel R. Witte
- Department of Public Health, Aarhus University
- Ivan Brandslund
- Department of Clinical Biochemistry, Lillebaelt Hospital
- Cramer Christensen
- Medical Department, Lillebaelt Hospital
- Torben Hansen
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Josep M. Mercader
- Program in Medical and Population Genetics, Broad Institute of Harvard and MIT
- Jason Flannick
- Program in Medical and Population Genetics, Broad Institute of Harvard and MIT
- Hortensia Moreno-Macías
- Universidad Autónomas Metropolitana
- Noël P. Burtt
- Program in Medical and Population Genetics, Broad Institute of Harvard and MIT
- Rong Zhang
- Department of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Young Jin Kim
- Division of Structural and Functional Genomics, Center for Genome Science, National Institute of Health
- Wei Zheng
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
- Jai Rup Singh
- Central University of Punjab
- Claudia H. T. Tam
- Department of Medicine and Therapeutics, The Chinese University of Hong Kong
- Hiroshi Hirose
- Health Center, Keio University
- Hiroshi Maegawa
- Department of Medicine, Shiga University of Medical Science
- Chikako Ito
- Grand Tower Medical Court Life Care Clinic
- Kohei Kaku
- Department of Internal Medicine, Kawasaki Medical School
- Hirotaka Watada
- Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine
- Yasushi Tanaka
- Division of Metabolism and Endocrinology, Department of Internal Medicine, St Marianna University School of Medicine
- Kazuyuki Tobe
- First Department of Internal Medicine, University of Toyama
- Ryuzo Kawamori
- Sportology Center, Juntendo University Graduate School of Medicine
- Michiaki Kubo
- RIKEN Center for Integrative Medical Sciences
- Yoon Shin Cho
- Department of Biomedical Science, Hallym University
- Juliana C. N. Chan
- Department of Medicine and Therapeutics, The Chinese University of Hong Kong
- Dharambir Sanghera
- Department of Pediatrics, University of Oklahoma Health Sciences Center
- Philippe Frossard
- Center for Non-Communicable Diseases
- Kyong Soo Park
- Department of Internal Medicine, Seoul National University Hospital
- Xiao-Ou Shu
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
- Bong-Jo Kim
- Division of Structural and Functional Genomics, Center for Genome Science, National Institute of Health
- Jose C. Florez
- Program in Medical and Population Genetics, Broad Institute of Harvard and MIT
- Teresa Tusié-Luna
- Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas UNAM/Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
- Weiping Jia
- Department of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- E Shyong Tai
- Saw Swee Hock School of Public Health, National University of Singapore
- Oluf Pedersen
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Danish Saleheen
- Department of Biostatistics and Epidemiology, University of Pennsylvania
- Shiro Maeda
- Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences
- Takashi Kadowaki
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo
- DOI
- https://doi.org/10.1038/ncomms10531
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 12
Abstract
Here, Imamuraet al. conduct meta-analysis of genome-wide association studies to identify novel susceptibility loci for type 2 diabetes (T2D) in the Japanese population. By doing so, this study shows that both ethnicity-specific and ethnically-shared genetic loci can contribute to T2D risk.
