ACS Central Science (Sep 2016)
Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles
- Alice E. Williamson,
- Paul M. Ylioja,
- Murray N. Robertson,
- Yevgeniya Antonova-Koch,
- Vicky Avery,
- Jonathan B. Baell,
- Harikrishna Batchu,
- Sanjay Batra,
- Jeremy N. Burrows,
- Soumya Bhattacharyya,
- Felix Calderon,
- Susan A. Charman,
- Julie Clark,
- Benigno Crespo,
- Matin Dean,
- Stefan L. Debbert,
- Michael Delves,
- Adelaide S. M. Dennis,
- Frederik Deroose,
- Sandra Duffy,
- Sabine Fletcher,
- Guri Giaever,
- Irene Hallyburton,
- Francisco-Javier Gamo,
- Marinella Gebbia,
- R. Kiplin Guy,
- Zoe Hungerford,
- Kiaran Kirk,
- Maria J. Lafuente-Monasterio,
- Anna Lee,
- Stephan Meister,
- Corey Nislow,
- John P. Overington,
- George Papadatos,
- Luc Patiny,
- James Pham,
- Stuart A. Ralph,
- Andrea Ruecker,
- Eileen Ryan,
- Christopher Southan,
- Kumkum Srivastava,
- Chris Swain,
- Matthew J. Tarnowski,
- Patrick Thomson,
- Peter Turner,
- Iain M. Wallace,
- Timothy N. C. Wells,
- Karen White,
- Laura White,
- Paul Willis,
- Elizabeth A. Winzeler,
- Sergio Wittlin,
- Matthew H. Todd
Affiliations
- Alice E. Williamson
- School of Chemistry, The University of Sydney, Sydney, New South Wales, Australia
- Paul M. Ylioja
- School of Chemistry, The University of Sydney, Sydney, New South Wales, Australia
- Murray N. Robertson
- School of Chemistry, The University of Sydney, Sydney, New South Wales, Australia
- Yevgeniya Antonova-Koch
- Department of Pediatrics, Pharmacology & Drug Development, University of California San Diego, La Jolla, California, United States
- Vicky Avery
- Discovery Biology, Eskitis Institute for Drug Discovery, Griffith University, Nathan, Queensland, Australia
- Jonathan B. Baell
- Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
- Harikrishna Batchu
- CSIR-Central Drug Research Institute, Lucknow, India
- Sanjay Batra
- CSIR-Central Drug Research Institute, Lucknow, India
- Jeremy N. Burrows
- Medicines for Malaria Venture, Geneva 15, Switzerland
- Soumya Bhattacharyya
- CSIR-Central Drug Research Institute, Lucknow, India
- Felix Calderon
- Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Spain
- Susan A. Charman
- Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
- Julie Clark
- Department of Chemical Biology & Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States
- Benigno Crespo
- Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Spain
- Matin Dean
- School of Chemistry, The University of Sydney, Sydney, New South Wales, Australia
- Stefan L. Debbert
- Department of Chemistry, Lawrence University, Appleton, Wisconsin, United States
- Michael Delves
- Department of Life Sciences, Imperial College London, London, U.K.
- Adelaide S. M. Dennis
- Research School of Biology, The Australian National University, Canberra, Australia
- Frederik Deroose
- Asclepia Outsourcing Solutions, Destelbergen, Belgium
- Sandra Duffy
- Discovery Biology, Eskitis Institute for Drug Discovery, Griffith University, Nathan, Queensland, Australia
- Sabine Fletcher
- Discovery Biology, Eskitis Institute for Drug Discovery, Griffith University, Nathan, Queensland, Australia
- Guri Giaever
- Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada
- Irene Hallyburton
- Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, U.K.
- Francisco-Javier Gamo
- Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Spain
- Marinella Gebbia
- Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada
- R. Kiplin Guy
- Department of Chemical Biology & Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States
- Zoe Hungerford
- School of Chemistry, The University of Sydney, Sydney, New South Wales, Australia
- Kiaran Kirk
- Research School of Biology, The Australian National University, Canberra, Australia
- Maria J. Lafuente-Monasterio
- Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Spain
- Anna Lee
- Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada
- Stephan Meister
- Department of Pediatrics, Pharmacology & Drug Development, University of California San Diego, La Jolla, California, United States
- Corey Nislow
- Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada
- John P. Overington
- European Molecular Biology LaboratoryEuropean Bioinformatics Institute, Hinxton, Cambridgeshire, U.K.
- George Papadatos
- European Molecular Biology LaboratoryEuropean Bioinformatics Institute, Hinxton, Cambridgeshire, U.K.
- Luc Patiny
- Institute of Chemical Sciences and Engineering (ISIC), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
- James Pham
- Department of Biochemistry & Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia
- Stuart A. Ralph
- Department of Biochemistry & Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia
- Andrea Ruecker
- Department of Life Sciences, Imperial College London, London, U.K.
- Eileen Ryan
- Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
- Christopher Southan
- IUPHAR/BPS Guide to PHARMACOLOGY, Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh, U.K.
- Kumkum Srivastava
- CSIR-Central Drug Research Institute, Lucknow, India
- Chris Swain
- Cambridge MedChem Consulting, Duxford, Cambridge, U.K.
- Matthew J. Tarnowski
- School of Chemistry, The University of Sydney, Sydney, New South Wales, Australia
- Patrick Thomson
- School of Chemistry, The University of Edinburgh, Edinburgh, U.K.
- Peter Turner
- School of Chemistry, The University of Sydney, Sydney, New South Wales, Australia
- Iain M. Wallace
- European Molecular Biology LaboratoryEuropean Bioinformatics Institute, Hinxton, Cambridgeshire, U.K.
- Timothy N. C. Wells
- Medicines for Malaria Venture, Geneva 15, Switzerland
- Karen White
- Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
- Laura White
- School of Chemistry, The University of Sydney, Sydney, New South Wales, Australia
- Paul Willis
- Medicines for Malaria Venture, Geneva 15, Switzerland
- Elizabeth A. Winzeler
- Department of Pediatrics, Pharmacology & Drug Development, University of California San Diego, La Jolla, California, United States
- Sergio Wittlin
- Swiss Tropical and Public Health Institute, Basel, Switzerland
- Matthew H. Todd
- School of Chemistry, The University of Sydney, Sydney, New South Wales, Australia
- DOI
- https://doi.org/10.1021/acscentsci.6b00086
- Journal volume & issue
-
Vol. 2,
no. 10
pp. 687 – 701
Abstract
No abstracts available.
