Nature Communications (Dec 2018)
uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis
- Tania Durré,
- Florent Morfoisse,
- Charlotte Erpicum,
- Marie Ebroin,
- Silvia Blacher,
- Melissa García-Caballero,
- Christophe Deroanne,
- Thomas Louis,
- Cédric Balsat,
- Maureen Van de Velde,
- Seppo Kaijalainen,
- Frédéric Kridelka,
- Lars Engelholm,
- Ingrid Struman,
- Kari Alitalo,
- Niels Behrendt,
- Jenny Paupert,
- Agnès Noel
Affiliations
- Tania Durré
- Laboratory of Tumor and Development Biology, GIGA (GIGA-Cancer), Liege University
- Florent Morfoisse
- Laboratory of Tumor and Development Biology, GIGA (GIGA-Cancer), Liege University
- Charlotte Erpicum
- Laboratory of Tumor and Development Biology, GIGA (GIGA-Cancer), Liege University
- Marie Ebroin
- Laboratory of Tumor and Development Biology, GIGA (GIGA-Cancer), Liege University
- Silvia Blacher
- Laboratory of Tumor and Development Biology, GIGA (GIGA-Cancer), Liege University
- Melissa García-Caballero
- Laboratory of Tumor and Development Biology, GIGA (GIGA-Cancer), Liege University
- Christophe Deroanne
- Laboratory of Connective Tissues Biology, GIGA-Cancer, Liege University
- Thomas Louis
- Laboratory of Tumor and Development Biology, GIGA (GIGA-Cancer), Liege University
- Cédric Balsat
- Laboratory of Tumor and Development Biology, GIGA (GIGA-Cancer), Liege University
- Maureen Van de Velde
- Laboratory of Tumor and Development Biology, GIGA (GIGA-Cancer), Liege University
- Seppo Kaijalainen
- Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki
- Frédéric Kridelka
- Laboratory of Tumor and Development Biology, GIGA (GIGA-Cancer), Liege University
- Lars Engelholm
- The Finsen Laboratory/BRIC, Rigshospitalet/University of Copenhagen
- Ingrid Struman
- Laboratory of Molecular Angiogenesis, GIGA-Cancer, Liege University
- Kari Alitalo
- Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki
- Niels Behrendt
- The Finsen Laboratory/BRIC, Rigshospitalet/University of Copenhagen
- Jenny Paupert
- Laboratory of Tumor and Development Biology, GIGA (GIGA-Cancer), Liege University
- Agnès Noel
- Laboratory of Tumor and Development Biology, GIGA (GIGA-Cancer), Liege University
- DOI
- https://doi.org/10.1038/s41467-018-07514-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
VEGF-C drives lymphangiogenesis through binding to its receptors VEGFR-2 and VEGFR-3. Here, Durré et al. identify uPARAP/Endo180 as a critical regulator of VEGFR-2/VEGFR-3 heterodimerisation and downstream signaling in response to VEGF-C, and show that uPARAP deletion leads to the formation of hyperbranched vasculatures in pathological conditions.
