Cells (Jul 2024)

Managing Patients with Hypereosinophilic Syndrome: A Statement from the Italian Society of Allergy, Asthma, and Clinical Immunology (SIAAIC)

  • Marco Caminati,
  • Luisa Brussino,
  • Matilde Carlucci,
  • Palma Carlucci,
  • Lucia Federica Carpagnano,
  • Cristiano Caruso,
  • Lorenzo Cosmi,
  • Simona D’Amore,
  • Stefano Del Giacco,
  • Aikaterini Detoraki,
  • Mario Di Gioacchino,
  • Andrea Matucci,
  • Ilaria Mormile,
  • Francescopaolo Granata,
  • Gabriella Guarnieri,
  • Mauro Krampera,
  • Matteo Maule,
  • Eustachio Nettis,
  • Stefania Nicola,
  • Silvia Noviello,
  • Fabrizio Pane,
  • Cristina Papayannidis,
  • Paola Parronchi,
  • Girolamo Pelaia,
  • Erminia Ridolo,
  • Francesca Wanda Rossi,
  • Gianenrico Senna,
  • Massimo Triggiani,
  • Angelo Vacca,
  • Emanuele Vivarelli,
  • Alessandra Vultaggio,
  • Amato de Paulis

DOI
https://doi.org/10.3390/cells13141180
Journal volume & issue
Vol. 13, no. 14
p. 1180

Abstract

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Hypereosinophilic syndrome (HES) encompasses a heterogeneous and complex group of different subtypes within the wider group of hypereosinophilic disorders. Despite increasing research interest, several unmet needs in terms of disease identification, pathobiology, phenotyping, and personalized treatment remain to be addressed. Also, the prospective burden of non-malignant HES and, more in general, HE disorders is currently unknown. On a practical note, shortening the diagnostic delay and the time to an appropriate treatment approach probably represents the most urgent issue, even in light of the great impact of HES on the quality of life of affected patients. The present document represents the first action that the Italian Society of Allergy, Asthma, and Clinical Immunology (SIAAIC) has finalized within a wider project aiming to establish a collaborative national network on HES (InHES—Italian Network on HES) for patients and physicians. The first step of the project could not but focus on defining a common language as well as sharing with all of the medical community an update on the most recent advances in the field. In fact, the existing literature has been carefully reviewed in order to critically integrate the different views on the topic and derive practical recommendations on disease identification and treatment approaches.

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