Nature Communications (Jan 2019)
Mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration
- Min Zhao,
- Irmela Mantel,
- Emmanuelle Gelize,
- Xinxin Li,
- Xiaoyue Xie,
- Alejandro Arboleda,
- Marie Seminel,
- Rinath Levy-Boukris,
- Marilyn Dernigoghossian,
- Andrea Prunotto,
- Charlotte Andrieu-Soler,
- Carlo Rivolta,
- Jérémie Canonica,
- Marie-Christine Naud,
- Sebastian Lechner,
- Nicolette Farman,
- Irene Bravo-Osuna,
- Rocio Herrero-Vanrell,
- Frederic Jaisser,
- Francine Behar-Cohen
Affiliations
- Min Zhao
- Inserm UMR_S 1138, Team 17, Centre de Recherche des Cordeliers
- Irmela Mantel
- Department of Ophthalmology, University of Lausanne, Jules Gonin Eye Hospital, Fondation Asile des Aveugles
- Emmanuelle Gelize
- Inserm UMR_S 1138, Team 17, Centre de Recherche des Cordeliers
- Xinxin Li
- Inserm UMR_S 1138, Team 17, Centre de Recherche des Cordeliers
- Xiaoyue Xie
- Inserm UMR_S 1138, Team 17, Centre de Recherche des Cordeliers
- Alejandro Arboleda
- Inserm UMR_S 1138, Team 17, Centre de Recherche des Cordeliers
- Marie Seminel
- Inserm UMR_S 1138, Team 17, Centre de Recherche des Cordeliers
- Rinath Levy-Boukris
- Inserm UMR_S 1138, Team 17, Centre de Recherche des Cordeliers
- Marilyn Dernigoghossian
- Inserm UMR_S 1138, Team 17, Centre de Recherche des Cordeliers
- Andrea Prunotto
- Department of Computational Biology, Unit of Medical Genetics, University of Lausanne
- Charlotte Andrieu-Soler
- IGMM, CNRS, Univ. Montpellier
- Carlo Rivolta
- Department of Computational Biology, Unit of Medical Genetics, University of Lausanne
- Jérémie Canonica
- Department of Ophthalmology, University of Lausanne, Jules Gonin Eye Hospital, Fondation Asile des Aveugles
- Marie-Christine Naud
- Inserm UMR_S 1138, Team 17, Centre de Recherche des Cordeliers
- Sebastian Lechner
- Sorbonne University, University of Pierre et Marie Curie, UMR_S 1138, Centre de Recherche des Cordeliers
- Nicolette Farman
- Sorbonne University, University of Pierre et Marie Curie, UMR_S 1138, Centre de Recherche des Cordeliers
- Irene Bravo-Osuna
- Department of Pharmacy and Pharmaceutical Technology, Universidad Complutense de Madrid
- Rocio Herrero-Vanrell
- Department of Pharmacy and Pharmaceutical Technology, Universidad Complutense de Madrid
- Frederic Jaisser
- Sorbonne University, University of Pierre et Marie Curie, UMR_S 1138, Centre de Recherche des Cordeliers
- Francine Behar-Cohen
- Inserm UMR_S 1138, Team 17, Centre de Recherche des Cordeliers
- DOI
- https://doi.org/10.1038/s41467-018-08125-6
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Current treatments for age-related neovascular macular degeneration (nAMD) suffer from limited efficacy. Here, Zhao et al. show that pharmacological inhibition or genetic deletion of the mineralocorticoid receptor (MR) limits choroidal neovascularisation in rodents, and show in a pilot clinical study that targeting the MR pathway may provide clinical benefits in nAMD patiens.
