Chemical synthesis, spectral characterization and biological activities of new diphenylsulphone derived Schiff base ligand and their Ni(II) complexes

Kundalkesha D. Gaikwad; Rahul M. Khobragade; Sachin A. Deodware; Panchsheela A. Ubale; Pratibha C. Dhale; Rekha M. Ovhal; Chandan Shivamallu; Veena Malligere Ankegowda; H.L. Raghavendra; Shashikant H. Gaikwad; Shiva Prasad Kollur

Results in Chemistry (Jan 2022)

Chemical synthesis, spectral characterization and biological activities of new diphenylsulphone derived Schiff base ligand and their Ni(II) complexes

Kundalkesha D. Gaikwad,
Rahul M. Khobragade,
Sachin A. Deodware,
Panchsheela A. Ubale,
Pratibha C. Dhale,
Rekha M. Ovhal,
Chandan Shivamallu,
Veena Malligere Ankegowda,
H.L. Raghavendra,
Shashikant H. Gaikwad,
Shiva Prasad Kollur

Affiliations

Kundalkesha D. Gaikwad: Chemistry Research Laboratory, Department of Chemistry, Shri Shivaji Mahavidyalaya, Barshi, Solapur 413 411, Maharashtra, India
Rahul M. Khobragade: Department of Microbiology, Dr. Babasaheb Ambedkar Marathwada University, Sub Campus, Osmanabad 413501, Maharashtra, India
Sachin A. Deodware: Chemistry Research Laboratory, Department of Chemistry, Shri Shivaji Mahavidyalaya, Barshi, Solapur 413 411, Maharashtra, India
Panchsheela A. Ubale: N.K. Orchid College of Engineering and Technology, Solapur 413002, Maharasthra, India
Pratibha C. Dhale: Chemistry Research Laboratory, Department of Chemistry, Shri Shivaji Mahavidyalaya, Barshi, Solapur 413 411, Maharashtra, India
Rekha M. Ovhal: Department of Chemistry, Walchand College of Art, Science and Commerce, Solapur 413 006, Maharashtra, India
Chandan Shivamallu: Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru, Karnataka 570 015, India
Veena Malligere Ankegowda: Department in Chemistry, Bangalore Institute of Technology, K.R. Road, VV Puram, Bangalore 560 004, Karnataka, India
H.L. Raghavendra: Centre for Biotechnology, Pravara Institute of Medical Sciences (Deemed to be University), Loni – 413 736, Ahmednagar, Maharashtra, India
Shashikant H. Gaikwad: Chemistry Research Laboratory, Department of Chemistry, Shri Shivaji Mahavidyalaya, Barshi, Solapur 413 411, Maharashtra, India; Corresponding authors.
Shiva Prasad Kollur: School of Physical Sciences, Amrita Vishwa Vidyapeetham, Mysuru Campus, Mysuru, Karnataka 570 026, India; Corresponding authors.

Journal volume & issue: Vol. 4
p. 100617

Abstract

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This work presents the preparation and spectral characterization of five diphenylsulphone derived Schiff base ligands (L1–L5). Using the aforementioned ligands, Ni(II) complexes were synthesized in 1:1 stoichiometric ratio. The synthesized ligands and their complexes were characterized by elemental analysis, 1H NMR, UV–Visible, FT-IR, ESI-MS, TGA analysis and magnetic susceptibility measurements.The results from the above analytical techniques revealed that the complexes are in an octahedral geometry. The antimicrobial activity of the synthesized Schiff base ligands and their metal complexes under study was carried out by using the agar well diffusion method. Further, the anticancer properties of the synthesized compounds are performed against MCF-7 cell line and human lung cancer cell line A-549 using Adriamycin as standard drug. The biological potency of the metal complexes were significant than their respective ligands.

Published in Results in Chemistry

ISSN: 2211-7156 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Chemistry
Website: https://www.journals.elsevier.com/results-in-chemistry/

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