Fullerenyl-1,2,3-Triazoles: Synthesis and Cytotoxic Activity

Abstract

Through the reaction of fullerenylazide with terminal acetylenes, previously undescribed 1-butyl-2-triazolylfullerenes, in which the heterocyclic fragment was directly attached to the fullerene backbone, were synthesized for the first time. Water-soluble complexes of the synthesized adducts of fullerene with polyvinylpyrrolidone showed a high cytotoxic activity towards tumor cells of the Jurkat, K562, and U937 lines.

Keywords

• fullerenylazide
• terminal alkynes
• click-reaction
• triazolofullerenes
• cytotoxic activity