Frontiers in Neuroscience (Jul 2020)
Progress in LRRK2-Associated Parkinson’s Disease Animal Models
- Steven P. Seegobin,
- Steven P. Seegobin,
- Steven P. Seegobin,
- George R. Heaton,
- George R. Heaton,
- George R. Heaton,
- Dongxiao Liang,
- Dongxiao Liang,
- Dongxiao Liang,
- Dongxiao Liang,
- Insup Choi,
- Insup Choi,
- Insup Choi,
- Marian Blanca Ramirez,
- Marian Blanca Ramirez,
- Marian Blanca Ramirez,
- Beisha Tang,
- Beisha Tang,
- Zhenyu Yue,
- Zhenyu Yue,
- Zhenyu Yue
Affiliations
- Steven P. Seegobin
- Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Steven P. Seegobin
- Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Steven P. Seegobin
- Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- George R. Heaton
- Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- George R. Heaton
- Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- George R. Heaton
- Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Dongxiao Liang
- Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Dongxiao Liang
- Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Dongxiao Liang
- Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Dongxiao Liang
- Department of Neurology, Xiangya Hospital, Central South University, Hunan, China
- Insup Choi
- Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Insup Choi
- Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Insup Choi
- Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Marian Blanca Ramirez
- Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Marian Blanca Ramirez
- Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Marian Blanca Ramirez
- Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Beisha Tang
- Department of Neurology, Xiangya Hospital, Central South University, Hunan, China
- Beisha Tang
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Hunan, China
- Zhenyu Yue
- Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Zhenyu Yue
- Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Zhenyu Yue
- Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- DOI
- https://doi.org/10.3389/fnins.2020.00674
- Journal volume & issue
-
Vol. 14
Abstract
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most frequent cause of familial Parkinson’s disease (PD). Several genetic manipulations of the LRRK2 gene have been developed in animal models such as rodents, Drosophila, Caenorhabditis elegans, and zebrafish. These models can help us further understand the biological function and derive potential pathological mechanisms for LRRK2. Here we discuss common phenotypic themes found in LRRK2-associated PD animal models, highlight several issues that should be addressed in future models, and discuss emerging areas to guide their future development.
Keywords
