Nature Communications (Sep 2022)
The nucleolus is the site for inflammatory RNA decay during infection
- Taeyun A. Lee,
- Heonjong Han,
- Ahsan Polash,
- Seok Keun Cho,
- Ji Won Lee,
- Eun A. Ra,
- Eunhye Lee,
- Areum Park,
- Sujin Kang,
- Junhee L. Choi,
- Ji Hyun Kim,
- Ji Eun Lee,
- Kyung-Won Min,
- Seong Wook Yang,
- Markus Hafner,
- Insuk Lee,
- Je-Hyun Yoon,
- Sungwook Lee,
- Boyoun Park
Affiliations
- Taeyun A. Lee
- Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University
- Heonjong Han
- Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University
- Ahsan Polash
- Laboratory of Muscle Stem Cells and Gene Regulation, National Institute for Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health
- Seok Keun Cho
- Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University
- Ji Won Lee
- Department of Biology, College of Natural Sciences, Gangneung-Wonju National University
- Eun A. Ra
- Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University
- Eunhye Lee
- Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University
- Areum Park
- Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University
- Sujin Kang
- Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University
- Junhee L. Choi
- Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University
- Ji Hyun Kim
- Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University
- Ji Eun Lee
- Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University
- Kyung-Won Min
- Department of Biology, College of Natural Sciences, Gangneung-Wonju National University
- Seong Wook Yang
- Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University
- Markus Hafner
- Laboratory of Muscle Stem Cells and Gene Regulation, National Institute for Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health
- Insuk Lee
- Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University
- Je-Hyun Yoon
- Department of Biochemistry and Molecular Biology, Medical University of South Carolina
- Sungwook Lee
- Division of Tumor Immunology, Research Institute, National Cancer Center
- Boyoun Park
- Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University
- DOI
- https://doi.org/10.1038/s41467-022-32856-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
The nucleolus is the traditional site for ribosomal RNA biogenesis. Here, the authors find that the nucleolus is a site of inflammatory pre-mRNA turnover and elucidated how immune homeostasis can be maintained by controlling inflammatory gene expression.
