Nature Communications (Jun 2021)

An antibody against L1 cell adhesion molecule inhibits cardiotoxicity by regulating persistent DNA damage

  • Jae-Kyung Nam,
  • A-Ram Kim,
  • Seo-Hyun Choi,
  • Ji-Hee Kim,
  • Kyu Jin Choi,
  • Seulki Cho,
  • Jae Won Lee,
  • Hyun-Jai Cho,
  • Yoo-Wook Kwon,
  • Jaeho Cho,
  • Kwang Seok Kim,
  • Joon Kim,
  • Hae-June Lee,
  • Tae Sup Lee,
  • Sangwoo Bae,
  • Hyo Jeong Hong,
  • Yoon-Jin Lee

DOI
https://doi.org/10.1038/s41467-021-23478-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 18

Abstract

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Mechanisms underlying the cardiotoxicity associated with thoracic irradiation and doxorubicin treatment during anticancer therapy remain poorly understood. Here the authors show that treatment with an antibody against the L1 cell adhesion molecule inhibits nuclear L1CAM translocation, thereby controlling vascular DNA damage and preventing cardiotoxicity.