Antioxidants (May 2021)

Keap1/Nrf2 Signaling Pathway

  • Gerasimos P. Sykiotis

DOI
https://doi.org/10.3390/antiox10060828
Journal volume & issue
Vol. 10, no. 6
p. 828

Abstract

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Nuclear factor, erythroid 2-like transcription factor 2 (Nrf2) and its cytoplasmic inhibitor, kelch-like ECH-associated protein 1 (Keap1), comprise a redox-responsive endogenous antioxidant defense module that orchestrates the expression of cytoprotective genes to maintain homeostasis [...]

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