TOXICITY OF HYPOFRACTIONATED RADIATION THERAPY FOR LOCALLY ADVANCED PROSTATE CANCER

Abstract

Objective: To study the frequency of complications after hypofractionated and standard fractionation radiation therapy in patients with locally advanced prostate cancer. Material and methods: The material of the study was the results of examination and treatment of 100 patients suffering from stage 3-4 prostate cancer (T3-4Nx-1M0). The patients were divided into two groups: those treated with hypofractionated radiotherapy regimen and those receiving standard fractionation radiation therapy. All patients were irradiated using a linear accelerator with obligatory control of the target position in real time. Conclusions: The use of modern high-tech methods of radiation therapy, as well as new methods of irradiation, providing for an optimal distribution of the radiation dose in the irradiated volume and in time, makes it possible to reduce the rate of acute and late radiation damage to normal tissues.

Keywords

• prostate cancer
• radiation therapy
• hypofractionation
• acute and late radiation damage