Nature Communications (Apr 2018)
A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration
- Salvatore Corallino,
- Chiara Malinverno,
- Beate Neumann,
- Christian Tischer,
- Andrea Palamidessi,
- Emanuela Frittoli,
- Magdalini Panagiotakopoulou,
- Andrea Disanza,
- Gema Malet-Engra,
- Paulina Nastaly,
- Camilla Galli,
- Chiara Luise,
- Giovanni Bertalot,
- Salvatore Pece,
- Pier Paolo Di Fiore,
- Nils Gauthier,
- Aldo Ferrari,
- Paolo Maiuri,
- Giorgio Scita
Affiliations
- Salvatore Corallino
- IFOM, the FIRC Institute of Molecular Oncology
- Chiara Malinverno
- IFOM, the FIRC Institute of Molecular Oncology
- Beate Neumann
- Advanced Light Microscopy Facility, European Molecular Biology Laboratory
- Christian Tischer
- Advanced Light Microscopy Facility, European Molecular Biology Laboratory
- Andrea Palamidessi
- IFOM, the FIRC Institute of Molecular Oncology
- Emanuela Frittoli
- IFOM, the FIRC Institute of Molecular Oncology
- Magdalini Panagiotakopoulou
- ETH Zurich, Laboratory of Thermodynamics in Emerging Technologies
- Andrea Disanza
- IFOM, the FIRC Institute of Molecular Oncology
- Gema Malet-Engra
- IFOM, the FIRC Institute of Molecular Oncology
- Paulina Nastaly
- IFOM, the FIRC Institute of Molecular Oncology
- Camilla Galli
- IFOM, the FIRC Institute of Molecular Oncology
- Chiara Luise
- Department of Experimental Oncology, European Institute of Oncology
- Giovanni Bertalot
- Department of Experimental Oncology, European Institute of Oncology
- Salvatore Pece
- Department of Experimental Oncology, European Institute of Oncology
- Pier Paolo Di Fiore
- IFOM, the FIRC Institute of Molecular Oncology
- Nils Gauthier
- IFOM, the FIRC Institute of Molecular Oncology
- Aldo Ferrari
- ETH Zurich, Laboratory of Thermodynamics in Emerging Technologies
- Paolo Maiuri
- IFOM, the FIRC Institute of Molecular Oncology
- Giorgio Scita
- IFOM, the FIRC Institute of Molecular Oncology
- DOI
- https://doi.org/10.1038/s41467-018-03571-8
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 19
Abstract
Circular dorsal ruffles (CDRs) are apical actin enriched structures involved in the interpretation of growth factor gradients during cell migration. Here, the authors find that a RAB35/PI3K axis is necessary and sufficient for the formation and stabilization of polarized CDRs and persistent directional migration.
