Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy

Davy Vanhoutte; Tobias G. Schips; Alexander Vo; Kelly M. Grimes; Tanya A. Baldwin; Matthew J. Brody; Federica Accornero; Michelle A. Sargent; Jeffery D. Molkentin

doi:10.1038/s41467-021-24215-4

Nature Communications (Jun 2021)

Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy

Davy Vanhoutte,
Tobias G. Schips,
Alexander Vo,
Kelly M. Grimes,
Tanya A. Baldwin,
Matthew J. Brody,
Federica Accornero,
Michelle A. Sargent,
Jeffery D. Molkentin

Affiliations

Davy Vanhoutte: Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center
Tobias G. Schips: Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center
Alexander Vo: Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center
Kelly M. Grimes: Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center
Tanya A. Baldwin: Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center
Matthew J. Brody: Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center
Federica Accornero: Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center
Michelle A. Sargent: Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center
Jeffery D. Molkentin: Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center

DOI: https://doi.org/10.1038/s41467-021-24215-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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Beneficial and detrimental effects have been ascribed to the different Thrombospondin (Thbs) proteins in the adult mammalian heart. Here, the authors show that Thbs1-mediated activation of PERK-eIF2α-ATF4-induced autophagy regulates adult cardiomyocyte size in the stressed heart.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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