Effect of probiotics therapy on intestinal leakage: A meta-analysis of randomized controlled trials

Abstract

Background: Currently, there is no clear conclusion regarding whether the ingestion of probiotics by humans can effectively maintain the intestinal physical barrier. The abundant bacterial population within intestinal tissues may encounter potential health issues, such as inflammation and infections. Therefore, the preservation of the integrity of the intestinal physical barrier plays a crucial role in reducing the body’s inflammatory response. However, further research is still needed to determine whether oral probiotics in humans can effectively maintain the functionality of this physical barrier. Objectives: This study aimed to investigate whether probiotic interventions alleviate intestinal leakage and strengthen intestinal barrier function. Methods: This systematic literature review and meta-analysis was conducted using three databases (PubMed, Science Direct, and ProQuest) to search for studies published from January 2010 to October 2020. Only randomized controlled trials of probiotic intervention for people with high intestinal permeability situations were included. Results: This meta-analysis included five randomized controlled trials, comprising 283 participants in total. Intestinal permeability was not significantly improved by probiotics intervention neither in short-time nor in long-term administrate. Conclusion: The meta-analysis study suggested that probiotics might not be an effective intervention for people with intestinal leakage. Probiotics might be considered as supplement food in maintaining normal intestinal permeability.

Keywords

• intestinal leakage
• intestinal permeability
• probiotic