Surface-enhanced Raman nanoparticles for tumor theranostics applications

Yangyang Li; Qiaolin Wei; Fei Ma; Xin Li; Fengyong Liu; Min Zhou

Acta Pharmaceutica Sinica B (May 2018)

Surface-enhanced Raman nanoparticles for tumor theranostics applications

Yangyang Li,
Qiaolin Wei,
Fei Ma,
Xin Li,
Fengyong Liu,
Min Zhou

Affiliations

Yangyang Li: Department of Nuclear Medicine & Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China; Institute of Translational Medicine, Zhejiang University, Hangzhou 310009, China
Qiaolin Wei: Department of Nuclear Medicine & Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China; Institute of Translational Medicine, Zhejiang University, Hangzhou 310009, China
Fei Ma: Department of Nuclear Medicine & Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China; Institute of Translational Medicine, Zhejiang University, Hangzhou 310009, China
Xin Li: Department of Interventional Radiology, Chinese PLA General Hospital, Beijing 100853, China
Fengyong Liu: Department of Interventional Radiology, Chinese PLA General Hospital, Beijing 100853, China; Corresponding author.
Min Zhou: Department of Nuclear Medicine & Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China; Institute of Translational Medicine, Zhejiang University, Hangzhou 310009, China; State Key Laboratory of Modern Optical Instrumentations, Zhejiang University, Hangzhou 310058, China; Corresponding author at: Department of Nuclear Medicine & Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.

Journal volume & issue: Vol. 8, no. 3
pp. 349 – 359

Abstract

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Raman spectroscopy, amplified by surface-enhanced Raman scattering (SERS) nanoparticles, can provide an in vivo imaging modality due to its high molecular specificity, high sensitivity, and negligible autofluorescence. The basis, composition, and methodologies developed for SERS nanoparticles are herein described. The research hotspots that are the focus in this paper are tumor imaging-guided theranostics and biosensing. The next breakthrough may be the development of biocompatible SERS nanoparticles and spectroscopic devices for clinical applications. KEY WORDS: Raman spectroscopy, SERS, Cancer imaging, Nanoparticles, Theranostics

Published in Acta Pharmaceutica Sinica B

ISSN: 2211-3835 (Print); 2211-3843 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.journals.elsevier.com/acta-pharmaceutica-sinica-b

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