PEX5 regulates autophagy via the mTORC1-TFEB axis during starvation

Abstract

Metabolism: A safeguard against cellular starvation A protein essential for the formation of peroxisomes—cellular organelles that perform diverse metabolic functions—also regulates cellular ‘recycling centers’ that break biomolecules down into nutrients. Researchers led by Raekil Park at the Gwangju Institute of Science and Technology in South Korea have now linked this protein, known as PEX5, to the function of another critical cellular organelle. Lysosomes participate in a process called autophagy, in which non-essential or damaged cellular components and biomolecules are digested to generate nutrients in times of deprivation. Park’s team determined that in the absence of PEX5, starved cells lose the ability to effectively initiate autophagy. They also identified the molecular pathways affected by PEX5 deficiency. These findings indicate a strong functional link between the peroxisome and lysosome, and could aid the development of treatments for certain metabolic disorders.