A Case of COVID-19 Pregnancy Complicated with Hydrops Fetalis and Intrauterine Death

Daniela Eugenia Popescu; Andreea Cioca; Cezara Muresan; Dan Navolan; Arina Gui; Ovidiu Pop; Tamara Marcovici; Constantin Ilie; Marius Craina; Marioara Boia

doi:10.3390/medicina57070667

Medicina (Jun 2021)

A Case of COVID-19 Pregnancy Complicated with Hydrops Fetalis and Intrauterine Death

Daniela Eugenia Popescu,
Andreea Cioca,
Cezara Muresan,
Dan Navolan,
Arina Gui,
Ovidiu Pop,
Tamara Marcovici,
Constantin Ilie,
Marius Craina,
Marioara Boia

Affiliations

Daniela Eugenia Popescu: Department of Neonatology, “Victor Babeş” University of Medicine and Pharmacy, Eftimie Murgu Sq. No.2, 300041 Timişoara, Romania
Andreea Cioca: Department of Pathology, Premiere Hospital, Regina Maria Health Network, Calea Aradului, No.113, 300645 Timişoara, Romania
Cezara Muresan: Department of Obstetrics and Gynecology, Premiere Hospital, Regina Maria Health Network, Calea Aradului, No.113, 300645 Timişoara, Romania
Dan Navolan: Department of Obstetrics and Gynecology, “Victor Babeş” University of Medicine and Pharmacy, Eftimie Murgu Sq. No.2, 300041 Timişoara, Romania
Arina Gui: Department of Obstetrics and Gynecology, Premiere Hospital, Regina Maria Health Network, Calea Aradului, No.113, 300645 Timişoara, Romania
Ovidiu Pop: Department of Morphological Sciences, University of Oradea, Universitatii Street, No.1, 410087 Oradea, Romania
Tamara Marcovici: Department of Pediatrics, First Pediatric Clinic, “Victor Babeş” University of Medicine and Pharmacy, Eftimie Murgu Sq. No.2, 300041 Timişoara, Romania
Constantin Ilie: Department of Neonatology, Regina Maria Health Network, Aristide Demetriade Street, No.1, 300088 Timisoara, Romania
Marius Craina: Department of Obstetrics and Gynecology, “Victor Babeş” University of Medicine and Pharmacy, Eftimie Murgu Sq. No.2, 300041 Timişoara, Romania
Marioara Boia: Department of Neonatology, “Victor Babeş” University of Medicine and Pharmacy, Eftimie Murgu Sq. No.2, 300041 Timişoara, Romania

DOI: https://doi.org/10.3390/medicina57070667
Journal volume & issue: Vol. 57, no. 7
p. 667

Abstract

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Coronavirus disease 2019 (COVID-19) has rapidly evolved into a worldwide pandemic causing a serious global public health problem. The risk of vertical transmission of SARS-CoV-2 is still debated, and the consequences of this virus on pregnant women and their fetuses remain unknown. We report a case of pregnancy complicated with hydrops fetalis that developed 7 weeks after recovery from a mild SARS-CoV-2 infection, leading to intrauterine death of the foetus. Evidence of SARS-CoV-2 placentitis was demonstrated by the presence of viral particles in the placenta identified by immunohistochemistry. As we excluded all possible etiological factors for non-immunologic hydrops fetalis, we believe that the fetal consequences of our case are related to vertical transmission of SARS-CoV-2 virus. To the best of our knowledge, this is the second reported case in the literature of COVID-19 infection complicated with hydrops fetalis and intrauterine fetal demise.

Published in Medicina

ISSN: 1010-660X (Print); 1648-9144 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General)
Website: https://www.mdpi.com/journal/medicina

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