Nature Communications (Aug 2016)

Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth

  • Marco Gerling,
  • Nikè V. J. A. Büller,
  • Leonard M. Kirn,
  • Simon Joost,
  • Oliver Frings,
  • Benjamin Englert,
  • Åsa Bergström,
  • Raoul V. Kuiper,
  • Leander Blaas,
  • Mattheus C. B. Wielenga,
  • Sven Almer,
  • Anja A. Kühl,
  • Erik Fredlund,
  • Gijs R. van den Brink,
  • Rune Toftgård

DOI
https://doi.org/10.1038/ncomms12321
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 17

Abstract

Read online

The Hedgehog signalling pathway can drive tumorigenesis. Here, the authors show that in a colitis-associated colon cancer model downstream Hedgehog signalling is restricted to the stroma and its over-activation can inhibit tumorigenesis, associated with activation of BMP signaling.