Leukemia Research Reports (Jan 2021)
Successful allogeneic bone marrow transplantation after massive gastrointestinal bleeding in a patient with myelodysplastic syndrome associated with intestinal Behçet-like disease
- Arata Ishii,
- Shokichi Tsukamoto,
- Tatsuzo Mishina,
- Shintaro Izumi,
- Yurie Nagai,
- Miki Yamazaki,
- Yutaro Hino,
- Kensuke Kayamori,
- Nagisa Oshima-Hasegawa,
- Tomoya Muto,
- Shio Mitsukawa,
- Yusuke Takeda,
- Naoya Mimura,
- Chikako Ohwada,
- Chiaki Nakaseko,
- Jun-ichiro Ikeda,
- Emiko Sakaida
Affiliations
- Arata Ishii
- Department of Hematology, Chiba University Hospital, Chiba, Japan; Blood and Marrow Transplant Center, Chiba University Hospital, Chiba, Japan
- Shokichi Tsukamoto
- Department of Hematology, Chiba University Hospital, Chiba, Japan; Blood and Marrow Transplant Center, Chiba University Hospital, Chiba, Japan; Corresponding author at: Department of Hematology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
- Tatsuzo Mishina
- Department of Hematology, Chiba University Hospital, Chiba, Japan; Blood and Marrow Transplant Center, Chiba University Hospital, Chiba, Japan
- Shintaro Izumi
- Department of Hematology, Chiba University Hospital, Chiba, Japan; Blood and Marrow Transplant Center, Chiba University Hospital, Chiba, Japan
- Yurie Nagai
- Department of Hematology, Chiba University Hospital, Chiba, Japan; Blood and Marrow Transplant Center, Chiba University Hospital, Chiba, Japan
- Miki Yamazaki
- Department of Hematology, Chiba University Hospital, Chiba, Japan; Blood and Marrow Transplant Center, Chiba University Hospital, Chiba, Japan
- Yutaro Hino
- Department of Hematology, Chiba University Hospital, Chiba, Japan; Blood and Marrow Transplant Center, Chiba University Hospital, Chiba, Japan
- Kensuke Kayamori
- Department of Hematology, Chiba University Hospital, Chiba, Japan; Blood and Marrow Transplant Center, Chiba University Hospital, Chiba, Japan
- Nagisa Oshima-Hasegawa
- Department of Hematology, Chiba University Hospital, Chiba, Japan; Blood and Marrow Transplant Center, Chiba University Hospital, Chiba, Japan
- Tomoya Muto
- Department of Hematology, Chiba University Hospital, Chiba, Japan; Blood and Marrow Transplant Center, Chiba University Hospital, Chiba, Japan
- Shio Mitsukawa
- Department of Hematology, Chiba University Hospital, Chiba, Japan; Department of Transfusion Medicine and Cell Therapy, Chiba University Hospital, Chiba, Japan
- Yusuke Takeda
- Department of Hematology, Chiba University Hospital, Chiba, Japan; Blood and Marrow Transplant Center, Chiba University Hospital, Chiba, Japan
- Naoya Mimura
- Department of Hematology, Chiba University Hospital, Chiba, Japan; Department of Transfusion Medicine and Cell Therapy, Chiba University Hospital, Chiba, Japan
- Chikako Ohwada
- Department of Hematology, Chiba University Hospital, Chiba, Japan; Blood and Marrow Transplant Center, Chiba University Hospital, Chiba, Japan; Department of Hematology, International University of Health and Welfare School of Medicine, Narita, Japan
- Chiaki Nakaseko
- Department of Hematology, Chiba University Hospital, Chiba, Japan; Blood and Marrow Transplant Center, Chiba University Hospital, Chiba, Japan; Department of Hematology, International University of Health and Welfare School of Medicine, Narita, Japan
- Jun-ichiro Ikeda
- Department of Pathology, Chiba University Hospital, Chiba, Japan
- Emiko Sakaida
- Department of Hematology, Chiba University Hospital, Chiba, Japan; Blood and Marrow Transplant Center, Chiba University Hospital, Chiba, Japan
- Journal volume & issue
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Vol. 16
p. 100278
Abstract
A 45-year-old woman was diagnosed with myelodysplastic syndrome (MDS) with trisomy 8 and Behçet-like disease (BLD) with multiple colorectal ulcers. Nonspecific inflammatory cells were infiltrated in the intestinal mucosa, whereas fluorescence in situ hybridization (FISH) analysis revealed only sporadic trisomy 8-positive cells. She presented massive lower gastrointestinal bleeding early after bone marrow transplantation but achieved long-term remission of both MDS and BLD. This is the first report of massive gastrointestinal bleeding after transplantation for MDS with BLD. Based on FISH analysis, dysregulation of systemic inflammation may be involved in BLD rather than direct invasion by trisomy 8-positive MDS clones.
