Journal of Medical Biochemistry (Jan 2022)

Evaluation of amino acid profile in serum of patients with Covid-19 for providing a new treatment strategy

  • Ozturk Ali,
  • Bayraktar Nihayet,
  • Bayraktar Mustafa,
  • Ibrahim Bashar,
  • Bozok Taylan,
  • Resat Ceylan Mehmet

DOI
https://doi.org/10.5937/jomb0-37514
Journal volume & issue
Vol. 41, no. 4
pp. 526 – 533

Abstract

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Background: Amino acids have an important role in metabolism and may affect COVID-19-related outcomes. In our study, the amino acid serum level of hospitalized COVID19 patients was evaluated to determine a new treatment strategy. Methods: The amino acid profile covering 43 amino acids in 68 subjects, comprising 30 (14 men and 16 women) controls and 38 (16 men and 22 women) COVID-19 patients, were examined. The amino acid profiles of the participants were screened by LC-MS/MS. Results: Compared with the control group, serum levels of 27 amino acids increased in the patient group. Alpha-aminopimelic acid, sarcosine, and hydroxyproline amino acids were considerably higher in the control group than in the patient group (p<0.0001). There was no notable difference among control group and the case group for 13 amino acids (p≥0.05). A significant positive correlation was seen among the control and the patient groups in the mean amino acid values (r=0.937; p<0.0001). Conclusions: These results postulated a clear picture on the serum levels of amino acid in the COVID-19 patients. Serum amino acids measured in hospitalized COVID-19 patients can explain the patient's metabolic status during the disease.

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