Recent Small-Molecule Inhibitors of the p53–MDM2 Protein–Protein Interaction

Abstract

This review presents the last decade of studies on the synthesis of various types of small-molecule inhibitors of the p53– Mouse double minute 2 homolog (MDM2) protein–protein interaction. The main focus is placed on synthetic approaches to such molecules, their cytotoxicity, and MDM2 binding characteristics.

Keywords

• p53–mdm2 inhibitors
• anticancer drugs
• cytotoxicity