Nature Communications (Mar 2019)
The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors
- Yihan Peng,
- Qingchao Liao,
- Wei Tan,
- Changmin Peng,
- Zhaohua Hu,
- Yali Chen,
- Zhuqing Li,
- Jing Li,
- Bei Zhen,
- Wenge Zhu,
- Xiangpan Li,
- Yi Yao,
- Qibin Song,
- Chengsheng Liu,
- Xiangdong Qi,
- Fuchu He,
- Huadong Pei
Affiliations
- Yihan Peng
- State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Proteome Research Center, Beijing Institute of Lifeomics
- Qingchao Liao
- State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Proteome Research Center, Beijing Institute of Lifeomics
- Wei Tan
- Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Science
- Changmin Peng
- Cancer Center, Renmin Hospital of Wuhan University
- Zhaohua Hu
- State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Proteome Research Center, Beijing Institute of Lifeomics
- Yali Chen
- State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Proteome Research Center, Beijing Institute of Lifeomics
- Zhuqing Li
- Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Science
- Jing Li
- Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Science
- Bei Zhen
- State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Proteome Research Center, Beijing Institute of Lifeomics
- Wenge Zhu
- Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Science
- Xiangpan Li
- Cancer Center, Renmin Hospital of Wuhan University
- Yi Yao
- Cancer Center, Renmin Hospital of Wuhan University
- Qibin Song
- Cancer Center, Renmin Hospital of Wuhan University
- Chengsheng Liu
- Aesthetic Surgery, Jingmei Cosmetic Surgery Clinic
- Xiangdong Qi
- Department of Plastic Surgery, General Hospital of Southern Theater Command
- Fuchu He
- State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Proteome Research Center, Beijing Institute of Lifeomics
- Huadong Pei
- State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Proteome Research Center, Beijing Institute of Lifeomics
- DOI
- https://doi.org/10.1038/s41467-019-09232-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Deubiquitinases have been shown to be involved in double strand break repair pathways. Here the authors reveal that USP15 deybiquitinase plays a role in homologues recombination repair by targeting BARD1 and affecting cells response to PARP inhibitors.
