Nature Communications (Jul 2018)
Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer
- Aurélie S. Cazet,
- Mun N. Hui,
- Benjamin L. Elsworth,
- Sunny Z. Wu,
- Daniel Roden,
- Chia-Ling Chan,
- Joanna N. Skhinas,
- Raphaël Collot,
- Jessica Yang,
- Kate Harvey,
- M. Zahied Johan,
- Caroline Cooper,
- Radhika Nair,
- David Herrmann,
- Andrea McFarland,
- Niantao Deng,
- Manuel Ruiz-Borrego,
- Federico Rojo,
- José M. Trigo,
- Susana Bezares,
- Rosalía Caballero,
- Elgene Lim,
- Paul Timpson,
- Sandra O’Toole,
- D. Neil Watkins,
- Thomas R. Cox,
- Michael S. Samuel,
- Miguel Martín,
- Alexander Swarbrick
Affiliations
- Aurélie S. Cazet
- Garvan Institute of Medical Research
- Mun N. Hui
- Garvan Institute of Medical Research
- Benjamin L. Elsworth
- MRC Integrative Epidemiology Unit, University of Bristol
- Sunny Z. Wu
- Garvan Institute of Medical Research
- Daniel Roden
- Garvan Institute of Medical Research
- Chia-Ling Chan
- Garvan Institute of Medical Research
- Joanna N. Skhinas
- Garvan Institute of Medical Research
- Raphaël Collot
- Garvan Institute of Medical Research
- Jessica Yang
- Garvan Institute of Medical Research
- Kate Harvey
- Garvan Institute of Medical Research
- M. Zahied Johan
- Centre for Cancer Biology, SA Pathology and the University of South Australia
- Caroline Cooper
- Pathology Queensland and School of Medicine, University of Queensland
- Radhika Nair
- Rajiv Gandhi Centre for Biotechnology
- David Herrmann
- Garvan Institute of Medical Research
- Andrea McFarland
- Garvan Institute of Medical Research
- Niantao Deng
- Garvan Institute of Medical Research
- Manuel Ruiz-Borrego
- Department of Medical Oncology, Hospital Universitario Virgen del Rocío
- Federico Rojo
- Department of Pathology, Hospital Universitario Fundación Jiménez Díaz
- José M. Trigo
- Department of Medical Oncology, Hospital Clínico Universitario Virgen de la Victoria, IBIMA
- Susana Bezares
- GEICAM, Spanish Breast Cancer Group
- Rosalía Caballero
- GEICAM, Spanish Breast Cancer Group
- Elgene Lim
- Garvan Institute of Medical Research
- Paul Timpson
- Garvan Institute of Medical Research
- Sandra O’Toole
- Garvan Institute of Medical Research
- D. Neil Watkins
- Garvan Institute of Medical Research
- Thomas R. Cox
- Garvan Institute of Medical Research
- Michael S. Samuel
- Centre for Cancer Biology, SA Pathology and the University of South Australia
- Miguel Martín
- Department of Medical Oncology, Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense, Centro de Investigación Biomédica en Red de Oncología, CIBERONC-ISCIII
- Alexander Swarbrick
- Garvan Institute of Medical Research
- DOI
- https://doi.org/10.1038/s41467-018-05220-6
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 18
Abstract
Stromal cell recruitment, activation and crosstalk with cancer cells is poorly understood. Here, the authors demonstrate that cancer cell-derived Hedgehog ligand triggers stromal remodeling that in turn induces a cancer-stem-cell like, drug-resistant phenotype of nearby cancer cells while treatment with smoothened inhibitors reverses these phenotypes.
