Transmissible Cancers in an Evolutionary Perspective

Antoine M. Dujon; Robert A. Gatenby; Georgina Bramwell; Nick MacDonald; Erin Dohrmann; Nynke Raven; Aaron Schultz; Rodrigo Hamede; Anne-Lise Gérard; Mathieu Giraudeau; Frédéric Thomas; Beata Ujvari

iScience (Jul 2020)

Transmissible Cancers in an Evolutionary Perspective

Antoine M. Dujon,
Robert A. Gatenby,
Georgina Bramwell,
Nick MacDonald,
Erin Dohrmann,
Nynke Raven,
Aaron Schultz,
Rodrigo Hamede,
Anne-Lise Gérard,
Mathieu Giraudeau,
Frédéric Thomas,
Beata Ujvari

Affiliations

Antoine M. Dujon: Deakin University, Geelong, School of Life and Environmental Sciences, Centre for Integrative Ecology, Waurn Ponds, Vic 3216, Australia
Robert A. Gatenby: Department of Radiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
Georgina Bramwell: Deakin University, Geelong, School of Life and Environmental Sciences, Centre for Integrative Ecology, Waurn Ponds, Vic 3216, Australia
Nick MacDonald: Deakin University, Geelong, School of Life and Environmental Sciences, Centre for Integrative Ecology, Waurn Ponds, Vic 3216, Australia
Erin Dohrmann: Deakin University, Geelong, School of Life and Environmental Sciences, Centre for Integrative Ecology, Waurn Ponds, Vic 3216, Australia
Nynke Raven: Deakin University, Geelong, School of Life and Environmental Sciences, Centre for Integrative Ecology, Waurn Ponds, Vic 3216, Australia
Aaron Schultz: Deakin University, Geelong, School of Life and Environmental Sciences, Centre for Integrative Ecology, Waurn Ponds, Vic 3216, Australia
Rodrigo Hamede: School of Natural Sciences, University of Tasmania, Private Bag 55, Hobart, TAS 7001, Australia
Anne-Lise Gérard: CREEC, UMR IRD 224-CNRS 5290-Université de Montpellier, Montpellier, France
Mathieu Giraudeau: CREEC, UMR IRD 224-CNRS 5290-Université de Montpellier, Montpellier, France
Frédéric Thomas: CREEC, UMR IRD 224-CNRS 5290-Université de Montpellier, Montpellier, France
Beata Ujvari: Deakin University, Geelong, School of Life and Environmental Sciences, Centre for Integrative Ecology, Waurn Ponds, Vic 3216, Australia; School of Natural Sciences, University of Tasmania, Private Bag 55, Hobart, TAS 7001, Australia; Corresponding author

Journal volume & issue: Vol. 23, no. 7
p. 101269

Abstract

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Inter-individual transmission of cancer cells represents an intriguing and unexplored host-pathogen system, with significant ecological and evolutionary ramifications. The pathogen consists of clonal malignant cell lines that spread horizontally as allografts and/or xenografts. Although only nine transmissible cancer lineages in eight host species from both terrestrial and marine environments have been investigated, they exhibit evolutionary dynamics that may provide novel insights into tumor-host interactions particularly in the formation of metastases. Here we present an overview of known transmissible cancers, discuss the necessary and sufficient conditions for cancer transmission, and provide a comprehensive review on the evolutionary dynamics between transmissible cancers and their hosts.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

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