PLoS ONE (Jan 2013)

Impact of PSCA variation on gastric ulcer susceptibility.

  • Chizu Tanikawa,
  • Keitaro Matsuo,
  • Michiaki Kubo,
  • Atsushi Takahashi,
  • Hidemi Ito,
  • Hideo Tanaka,
  • Yasushi Yatabe,
  • Kenji Yamao,
  • Naoyuki Kamatani,
  • Kazuo Tajima,
  • Yusuke Nakamura,
  • Koichi Matsuda

DOI
https://doi.org/10.1371/journal.pone.0063698
Journal volume & issue
Vol. 8, no. 5
p. e63698

Abstract

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Peptic ulcer is one of the most common gastrointestinal disorders with complex etiology. Recently we conducted the genome wide association study for duodenal ulcer and identified disease susceptibility variations at two genetic loci corresponding to the Prostate stem cell antigen (PSCA) gene and the ABO blood group (ABO) gene. Here we investigated the association of these variations with gastric ulcer in two Japanese case-control sample sets, a total of 4,291 gastric ulcer cases and 22,665 controls. As a result, a C-allele of rs2294008 at PSCA increased the risk of gastric ulcer with odds ratio (OR) of 1.13 (P value of 5.85×10(-7)) in an additive model. On the other hand, SNP rs505922 on ABO exhibited inconsistent result between two cohorts. Our finding implies presence of the common genetic variant in the pathogenesis of gastric and duodenal ulcers.