Ameliorated Effects of Green Tea Extract on Lead Induced Kidney Toxicity in Rats

Abstract

In the present study, the protective effect of an aqueous extract of green tea (GTE) against renal oxidative damage induced by lead was undertaken. Adult males rats were divided into 4 groups: Control group receives distilled water as sole drinking source. GTE group received green tea extract (6.6% w/v).Pb group received Pb at dose of 0.4 % w/v in distilled water. Pb + GTE group received mixture of Pb and GTE as sole drinking source. Renal oxidative damage was observed in Pb-treated rats as evidenced via augmentation in kidney lipid peroxidation (LPO) as well as depletion in kidney antioxidant enzymes; catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx). Histopathological analysis revealed degeneration in the endothelium of glomerular tuft and the epithelium of lining tubules. In conclusion, GTE appeared to be beneficial to rats, to a great extent by attenuating and restoring the damage sustained by lead exposure.

Keywords

• Green tea
• Lead
• Histopathology
• Nephrotoxicity