Frontiers in Oncology (Mar 2023)
Automatic bundle-specific white matter fiber tracking tool using diffusion tensor imaging data: A pilot trial in the application of language-related glioma resection
- Yifan Yuan,
- Yifan Yuan,
- Yifan Yuan,
- Yifan Yuan,
- Yifan Yuan,
- Yifan Yuan,
- Tianming Qiu,
- Tianming Qiu,
- Tianming Qiu,
- Tianming Qiu,
- Tianming Qiu,
- Tianming Qiu,
- Shin Tai Chong,
- Sanford Pin-Chuan Hsu,
- Ying-Hua Chu,
- Yi-Cheng Hsu,
- Geng Xu,
- Geng Xu,
- Geng Xu,
- Geng Xu,
- Geng Xu,
- Geng Xu,
- Yu-Ting Ko,
- Kuan-Tsen Kuo,
- Zixiao Yang,
- Zixiao Yang,
- Zixiao Yang,
- Zixiao Yang,
- Zixiao Yang,
- Zixiao Yang,
- Wei Zhu,
- Wei Zhu,
- Wei Zhu,
- Wei Zhu,
- Wei Zhu,
- Wei Zhu,
- Ching-Po Lin,
- Jianping Song,
- Jianping Song,
- Jianping Song,
- Jianping Song,
- Jianping Song,
- Jianping Song,
- Jianping Song
Affiliations
- Yifan Yuan
- Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
- Yifan Yuan
- National Center for Neurological Disorders, Shanghai, China
- Yifan Yuan
- Neurosurgical Institute of Fudan University, Shanghai, China
- Yifan Yuan
- Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
- Yifan Yuan
- Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China
- Yifan Yuan
- Research Units of New Technologies of Micro-Endoscopy Combination in Skull Base Surgery, Chinese Academy of Medical Sciences (CAMS), Shanghai, China
- Tianming Qiu
- Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
- Tianming Qiu
- National Center for Neurological Disorders, Shanghai, China
- Tianming Qiu
- Neurosurgical Institute of Fudan University, Shanghai, China
- Tianming Qiu
- Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
- Tianming Qiu
- Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China
- Tianming Qiu
- Research Units of New Technologies of Micro-Endoscopy Combination in Skull Base Surgery, Chinese Academy of Medical Sciences (CAMS), Shanghai, China
- Shin Tai Chong
- Institute of Neuroscience, National Yang Ming Chiao Tung University, Hsinchu, Taiwan
- Sanford Pin-Chuan Hsu
- Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
- Ying-Hua Chu
- Magnetic Resonance (MR) Collaboration, Siemens Healthineers Ltd., Shanghai, China
- Yi-Cheng Hsu
- Magnetic Resonance (MR) Collaboration, Siemens Healthineers Ltd., Shanghai, China
- Geng Xu
- Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
- Geng Xu
- National Center for Neurological Disorders, Shanghai, China
- Geng Xu
- Neurosurgical Institute of Fudan University, Shanghai, China
- Geng Xu
- Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
- Geng Xu
- Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China
- Geng Xu
- Research Units of New Technologies of Micro-Endoscopy Combination in Skull Base Surgery, Chinese Academy of Medical Sciences (CAMS), Shanghai, China
- Yu-Ting Ko
- Institute of Neuroscience, National Yang Ming Chiao Tung University, Hsinchu, Taiwan
- Kuan-Tsen Kuo
- Institute of Neuroscience, National Yang Ming Chiao Tung University, Hsinchu, Taiwan
- Zixiao Yang
- Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
- Zixiao Yang
- National Center for Neurological Disorders, Shanghai, China
- Zixiao Yang
- Neurosurgical Institute of Fudan University, Shanghai, China
- Zixiao Yang
- Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
- Zixiao Yang
- Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China
- Zixiao Yang
- Research Units of New Technologies of Micro-Endoscopy Combination in Skull Base Surgery, Chinese Academy of Medical Sciences (CAMS), Shanghai, China
- Wei Zhu
- Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
- Wei Zhu
- National Center for Neurological Disorders, Shanghai, China
- Wei Zhu
- Neurosurgical Institute of Fudan University, Shanghai, China
- Wei Zhu
- Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
- Wei Zhu
- Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China
- Wei Zhu
- Research Units of New Technologies of Micro-Endoscopy Combination in Skull Base Surgery, Chinese Academy of Medical Sciences (CAMS), Shanghai, China
- Ching-Po Lin
- Institute of Neuroscience, National Yang Ming Chiao Tung University, Hsinchu, Taiwan
- Jianping Song
- Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
- Jianping Song
- National Center for Neurological Disorders, Shanghai, China
- Jianping Song
- Neurosurgical Institute of Fudan University, Shanghai, China
- Jianping Song
- Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
- Jianping Song
- Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China
- Jianping Song
- Research Units of New Technologies of Micro-Endoscopy Combination in Skull Base Surgery, Chinese Academy of Medical Sciences (CAMS), Shanghai, China
- Jianping Song
- 0Department of Neurosurgery, National Regional Medical Center, Fudan University Huashan Hospital, Fuzhou, Fujian, China
- DOI
- https://doi.org/10.3389/fonc.2023.1089923
- Journal volume & issue
-
Vol. 13
Abstract
Cerebral neoplasms like gliomas may cause intracranial pressure increasing, neural tract deviation, infiltration, or destruction in peritumoral areas, leading to neuro-functional deficits. Novel tracking technology, such as DTI, can objectively reveal and visualize three-dimensional white matter trajectories; in combination with intraoperative navigation, it can help achieve maximum resection whilst minimizing neurological deficit. Since the reconstruction of DTI raw data largely relies on the technical engineering and anatomical experience of the operator; it is time-consuming and prone to operator-induced bias. Here, we develop new user-friendly software to automatically segment and reconstruct functionally active areas to facilitate precise surgery. In this pilot trial, we used an in-house developed software (DiffusionGo) specially designed for neurosurgeons, which integrated a reliable diffusion-weighted image (DWI) preprocessing pipeline that embedded several functionalities from software packages of FSL, MRtrix3, and ANTs. The preprocessing pipeline is as follows: 1. DWI denoising, 2. Gibbs-ringing removing, 3. Susceptibility distortion correction (process if opposite polarity data were acquired), 4. Eddy current and motion correction, and 5. Bias correction. Then, this fully automatic multiple assigned criteria algorithms for fiber tracking were used to achieve easy modeling and assist precision surgery. We demonstrated the application with three language-related cases in three different centers, including a left frontal, a left temporal, and a left frontal-temporal glioma, to achieve a favorable surgical outcome with language function preservation or recovery. The DTI tracking result using DiffusionGo showed robust consistency with direct cortical stimulation (DCS) finding. We believe that this fully automatic processing pipeline provides the neurosurgeon with a solution that may reduce time costs and operating errors and improve care quality and surgical procedure quality across different neurosurgical centers.
Keywords
- awake neurosurgery
- brain mapping
- diffusion tensor imaging
- functional neuroimaging
- white matter tracts fiber tracking software for neurosurgeon
