Communications Biology (Jun 2022)
Genome-wide meta-analysis of iron status biomarkers and the effect of iron on all-cause mortality in HUNT
- Marta R. Moksnes,
- Sarah E. Graham,
- Kuan-Han Wu,
- Ailin Falkmo Hansen,
- Sarah A. Gagliano Taliun,
- Wei Zhou,
- Ketil Thorstensen,
- Lars G. Fritsche,
- Dipender Gill,
- Amy Mason,
- Francesco Cucca,
- David Schlessinger,
- Gonçalo R. Abecasis,
- Stephen Burgess,
- Bjørn Olav Åsvold,
- Jonas B. Nielsen,
- Kristian Hveem,
- Cristen J. Willer,
- Ben M. Brumpton
Affiliations
- Marta R. Moksnes
- K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU – Norwegian University of Science and Technology
- Sarah E. Graham
- Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan
- Kuan-Han Wu
- Department of Computational Medicine and Bioinformatics, University of Michigan
- Ailin Falkmo Hansen
- K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU – Norwegian University of Science and Technology
- Sarah A. Gagliano Taliun
- Department of Medicine and Department of Neurosciences, Université de Montréal
- Wei Zhou
- Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital
- Ketil Thorstensen
- Department of Clinical Chemistry, St. Olavs hospital Trondheim University Hospital
- Lars G. Fritsche
- Department of Biostatistics, University of Michigan School of Public Health
- Dipender Gill
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Amy Mason
- British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
- Francesco Cucca
- Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR)
- David Schlessinger
- Laboratory of Genetics, National Institute on Aging, US National Institutes of Health
- Gonçalo R. Abecasis
- Center for Statistical Genetics, University of Michigan School of Public Health
- Stephen Burgess
- British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
- Bjørn Olav Åsvold
- K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU – Norwegian University of Science and Technology
- Jonas B. Nielsen
- K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU – Norwegian University of Science and Technology
- Kristian Hveem
- K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU – Norwegian University of Science and Technology
- Cristen J. Willer
- K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU – Norwegian University of Science and Technology
- Ben M. Brumpton
- K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU – Norwegian University of Science and Technology
- DOI
- https://doi.org/10.1038/s42003-022-03529-z
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 13
Abstract
A GWAS on the four major iron-related biomarkers is conducted using data from the Trøndelag Health Study (HUNT), Michigan Genomics Initiative (MGI), and SardiNIA study, to identify 123 loci associated with iron homeostasis and effect on all-cause mortality.
