Basic and Clinical Neuroscience (Jan 2009)

Neuroprotective effect of quercetin in a model of Parkinson’s disease in rat: A histochemical analysis

  • Mehdi Mehdizadeh,
  • Mohammad Taghi Joghataei,
  • Maliheh Nobakht,
  • Roya Aryanpour

Journal volume & issue
Vol. 1, no. 1
pp. 3 – 6

Abstract

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AbstractIntroduction: Parkinson's disease (PD) is a neuropathological disorder involving the degeneration of dopaminergic neurons in the substantia nigra, with the subsequent loss of their terminals in the striatum. Quercetin, a natural flavonoid, is a strong antioxidant and radical scavenger. Therefore, its neuroprotective effect in a model of Parkinson’s disease in rat was evaluated.Methods: For this purpose, unilateral intrastriatal 6-hydroxydopamine (6-OHDA)-lesioned rats were pretreated with quercetin (20 mg/kg; i.p.) 1 hour before surgery and treated once a day for one month. Nissl-stained neurons of substantia nigra pars compacta (SNC) were counted. Results: Number of Nissl-stained neurons in left side of SNC of lesion group was lower relative to sham-operated group (p<0.005) and it was higher in quercetin-treated lesion group as compared to untreated lesion group (p<0.01).Discussion: Flavonoid quercetin administration for one month could protect the neurons of SNC against 6-OHDA toxicity.

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