Evaluation of Oxidative Stress Parameters and Antioxidant Status in Diabetes Type 1 Patients at Dhi Qar, Iraq

Abstract

Background Oxidative stress and low antioxidant defense have a role in the initiation and progression of complications related to type 1 diabetic mellitus (T1DM). Objective of the study The study aims to evaluate oxidative stress parameters and antioxidant status, which were assessed, compared, and correlated with controls. Materials and Methods A case-control study design was employed from June 1, 2023, to February 1, 2024; the present study included 100 age ranges (30–75) years of clinically proven T1DM patients selected from Al Hussein Teaching Hospital and 100 controls in the same age range and with no history of T1DM were chosen after undergoing health checkups in the hospital. Measured were for HOMA IR, MDA, CAT, insulin, fasting blood sugar, haemoglobin A1C%, and T-AOC. Both inferential and descriptive statistical analyses were applied to the data. Results The results showed that MDA was considerably higher in pa- tients than in controls (P<0.05), although T-AOC and CAT were signifi- cantly lower in patients than in controls (P<0.05). T1DM patients showed significantly higher HOMA-IR, HbA1c, and insulin levels. Conclusion Patients with type 1 diabetes exhibit higher oxidative stress and a lower antioxidant level. Future therapy plans could focus on increasing antioxidants and lowering oxidative stress in patients with diabetes mellitus.

Keywords

• t1dm
• mda
• t-aoc
• cat
• insulin and homa ir