Unveiling the Antiviral Capabilities of Targeting Human Dihydroorotate Dehydrogenase against SARS-CoV‑2

• Aline D. Purificação,
• Sabrina Silva-Mendonça,
• Luiza V. Cruz,
• Carolina Q. Sacramento,
• Jairo R. Temerozo,
• Natalia Fintelman-Rodrigues,
• Caroline Souza de Freitas,
• Bruna Fleck Godoi,
• Miguel Menezes Vaidergorn,
• Juliana Almeida Leite,
• Luis Carlos Salazar Alvarez,
• Murillo V. Freitas,
• Meryck F. B. Silvac,
• Bianca A. Martin,
• Renata F. V. Lopez,
• Bruno J. Neves,
• Fabio T. M. Costa,
• Thiago M. L. Souza,
• Flavio da Silva Emery,
• Carolina Horta Andrade,
• M. Cristina Nonato

Affiliations

Aline D. Purificação

Protein Crystallography Laboratory, Department of Biomolecular Sciences, School of Pharmaceutical Sciences at Ribeirao Preto, University of São Paulo, Ribeirão Preto, SP, Brazil

Sabrina Silva-Mendonça

Center for the Research and Advancement in Fragments and molecular Targets (CRAFT), School of Pharmaceutical Sciences at Ribeirao Preto, University of São Paulo, Ribeirão Preto, SP, Brazil

Luiza V. Cruz

Center for the Research and Advancement in Fragments and molecular Targets (CRAFT), School of Pharmaceutical Sciences at Ribeirao Preto, University of São Paulo, Ribeirão Preto, SP, Brazil

Carolina Q. Sacramento

Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, RJ, Brazil

Jairo R. Temerozo

Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, RJ, Brazil

Natalia Fintelman-Rodrigues

Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, RJ, Brazil

Caroline Souza de Freitas

Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, RJ, Brazil

Bruna Fleck Godoi

Center for the Research and Advancement in Fragments and molecular Targets (CRAFT), School of Pharmaceutical Sciences at Ribeirao Preto, University of São Paulo, Ribeirão Preto, SP, Brazil

Miguel Menezes Vaidergorn

Center for the Research and Advancement in Fragments and molecular Targets (CRAFT), School of Pharmaceutical Sciences at Ribeirao Preto, University of São Paulo, Ribeirão Preto, SP, Brazil

Juliana Almeida Leite

Laboratory of Tropical Diseases, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, Unicamp, Campinas, SP, Brazil

Luis Carlos Salazar Alvarez

Laboratory of Tropical Diseases, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, Unicamp, Campinas, SP, Brazil

Murillo V. Freitas

Laboratory for Molecular Modeling and Drug Design (LabMol), Faculty of Pharmacy, Universidade Federal de Goiás, Goiânia, GO, Brazil

Meryck F. B. Silvac

Laboratory for Molecular Modeling and Drug Design (LabMol), Faculty of Pharmacy, Universidade Federal de Goiás, Goiânia, GO, Brazil

Bianca A. Martin

Innovation Center in Nanostructured Systems and Topical Administration (NanoTop), School of Pharmaceutical Sciences at Ribeirao Preto, University of São Paulo, Ribeirão Preto, SP, Brazil

Renata F. V. Lopez

Innovation Center in Nanostructured Systems and Topical Administration (NanoTop), School of Pharmaceutical Sciences at Ribeirao Preto, University of São Paulo, Ribeirão Preto, SP, Brazil

Bruno J. Neves

Laboratory of Cheminformatics, Faculty of Pharmacy, Universidade Federal de Goiás, Goiânia, GO, Brazil

Fabio T. M. Costa

Laboratory of Tropical Diseases, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, Unicamp, Campinas, SP, Brazil

Thiago M. L. Souza

Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, RJ, Brazil

Flavio da Silva Emery

Center for the Research and Advancement in Fragments and molecular Targets (CRAFT), School of Pharmaceutical Sciences at Ribeirao Preto, University of São Paulo, Ribeirão Preto, SP, Brazil

Carolina Horta Andrade

Center for the Research and Advancement in Fragments and molecular Targets (CRAFT), School of Pharmaceutical Sciences at Ribeirao Preto, University of São Paulo, Ribeirão Preto, SP, Brazil

M. Cristina Nonato

Protein Crystallography Laboratory, Department of Biomolecular Sciences, School of Pharmaceutical Sciences at Ribeirao Preto, University of São Paulo, Ribeirão Preto, SP, Brazil