Zn
2+
Intoxication of Mycobacterium marinum during Dictyostelium discoideum Infection Is Counteracted by Induction of the Pathogen Zn
2+
Exporter CtpC

Nabil Hanna; Hendrik Koliwer-Brandl; Louise H. Lefrançois; Vera Kalinina; Elena Cardenal-Muñoz; Joddy Appiah; Florence Leuba; Aurélie Gueho; Hubert Hilbi; Thierry Soldati; Caroline Barisch

doi:10.1128/mBio.01313-20

mBio (Feb 2021)

Zn 2+ Intoxication of Mycobacterium marinum during Dictyostelium discoideum Infection Is Counteracted by Induction of the Pathogen Zn 2+ Exporter CtpC

Nabil Hanna,
Hendrik Koliwer-Brandl,
Louise H. Lefrançois,
Vera Kalinina,
Elena Cardenal-Muñoz,
Joddy Appiah,
Florence Leuba,
Aurélie Gueho,
Hubert Hilbi,
Thierry Soldati,
Caroline Barisch

Affiliations

Nabil Hanna: ORCiD; Department of Biochemistry, Faculty of Science, University of Geneva, Geneva, Switzerland
Hendrik Koliwer-Brandl: ORCiD; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland
Louise H. Lefrançois: ORCiD; Department of Biochemistry, Faculty of Science, University of Geneva, Geneva, Switzerland
Vera Kalinina: ORCiD; Department of Biochemistry, Faculty of Science, University of Geneva, Geneva, Switzerland
Elena Cardenal-Muñoz: ORCiD; Department of Biochemistry, Faculty of Science, University of Geneva, Geneva, Switzerland
Joddy Appiah: ORCiD; Department of Biochemistry, Faculty of Science, University of Geneva, Geneva, Switzerland
Florence Leuba: ORCiD; Department of Biochemistry, Faculty of Science, University of Geneva, Geneva, Switzerland
Aurélie Gueho: ORCiD; Department of Biochemistry, Faculty of Science, University of Geneva, Geneva, Switzerland
Hubert Hilbi: ORCiD; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland
Thierry Soldati: ORCiD; Department of Biochemistry, Faculty of Science, University of Geneva, Geneva, Switzerland
Caroline Barisch: ORCiD; Department of Biochemistry, Faculty of Science, University of Geneva, Geneva, Switzerland

DOI: https://doi.org/10.1128/mBio.01313-20
Journal volume & issue: Vol. 12, no. 1

Abstract

Read online

Microelements are essential for the function of the innate immune system. A deficiency in zinc or copper results in an increased susceptibility to bacterial infections.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal