Does Mannose-Binding Lectin Gene Polymorphism in Pediatric Patients Undergoing Peritoneal Dialysis Cause Susceptibility to the Development of Peritonitis?

Abstract

Objective: This study aims to investigate the relationship between peritonitis attacks and mannose-binding lectin (MBL) gene polymorphism in patients undergoing peritoneal dialysis. Method: Codon 54 polymorphism found in exon 1 of the MBL gene was investigated by polymerase chain reaction-restriction fragment length polymorphism method in 45 patients with chronic renal failure undergoing peritoneal dialysis. Results: The frequency of the mutant B allele was not significantly higher in the patient group (4.4%) than the control group (2.1%). The AB genotype was found at a rate of 15.6% and 34% in the patient group and healthy control group, respectively. The AA genotype was found in 80% of children who underwent peritoneal dialysis and 63.8% of the healthy control group. Conclusion: In our study, no relationship was found between peritonitis attacks and MBL gene polymorphism in patients undergoing peritoneal dialysis.

Keywords

• peritoneal dialysis
• peritonitis
• mannose-binding lectin
• pcr