A neural m6A/Ythdf pathway is required for learning and memory in Drosophila

Lijuan Kan; Stanislav Ott; Brian Joseph; Eun Sil Park; Wei Dai; Ralph E. Kleiner; Adam Claridge-Chang; Eric C. Lai

doi:10.1038/s41467-021-21537-1

Nature Communications (Mar 2021)

A neural m6A/Ythdf pathway is required for learning and memory in Drosophila

Lijuan Kan,
Stanislav Ott,
Brian Joseph,
Eun Sil Park,
Wei Dai,
Ralph E. Kleiner,
Adam Claridge-Chang,
Eric C. Lai

Affiliations

Lijuan Kan: Department of Developmental Biology, Sloan-Kettering Institute
Stanislav Ott: Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School
Brian Joseph: Department of Developmental Biology, Sloan-Kettering Institute
Eun Sil Park: Department of Developmental Biology, Sloan-Kettering Institute
Wei Dai: Department of Chemistry, Princeton University
Ralph E. Kleiner: Department of Chemistry, Princeton University
Adam Claridge-Chang: Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School
Eric C. Lai: Department of Developmental Biology, Sloan-Kettering Institute

DOI: https://doi.org/10.1038/s41467-021-21537-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 18

Abstract

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Epitranscriptomic modifications can regulate learning and memory. Here, the authors provide proteomic and functional analysis of N6-methyladenosine (m6A)-binding proteins in D. melanogaster and unveil behavioral and regulatory defects for m6A/Ythdf mutants.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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